Volume 190, Issue 5
March 2013
Cover image
Cover image
On the cover: Whole-mount immunofluorescence analysis of the peripheral lymph node shows that autotaxin (blue) is abundantly expressed on the luminal surface of high endothelial venules (PNAd, red), which efficiently mediate extravasation of adoptively transferred GFP+ lymphocytes (green). Bai, Z., L. Cai, E. Umemoto, A. Takeda, K. Tohya, Y. Komai, P. T. Veeraveedu, E. Hata, Y. Sugiura, A. Kubo, M. Suematsu, H. Hayasaka, S. Okudaira, J. Aoki, T. Tanaka, H. M. H. G. Albers, H. Ovaa, and M. Miyasaka. 2013. Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acid axis. J. Immunol. 190: 2036–2048.
ISSN 0022-1767
EISSN 1550-6606
Issue navigation
Volume 190, Issue 5, March 2013
In This Issue
In This Issue
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 1893–1894, https://doi.org/10.4049/jimmunol.1390001
Letters to the Editor
Comment on “The Role of Naive T Cell Precursor Frequency and Recruitment in Dictating Immune Response Magnitude”
The Journal of Immunology, Volume 190, Issue 5, March 2013, Page 1895, https://doi.org/10.4049/jimmunol.1290079
Response to Comment on “The Role of Naive T Cell Precursor Frequency and Recruitment in Dictating Immune Response Magnitude”
The Journal of Immunology, Volume 190, Issue 5, March 2013, Page 1896, https://doi.org/10.4049/jimmunol.1290080
Pillars of Immunology
Helping Tumor Cells To Die
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 1897–1898, https://doi.org/10.4049/jimmunol.1300045
Pillars Article: Eradication of Disseminated Murine Leukemia by Chemoimmunotherapy with Cyclophosphamide and Adoptively Transferred Immune Syngeneic Lyt-1+2− Lymphocytes. J. Exp. Med. 1981. 154: 952–963
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 1899–1910, https://doi.org/10.1093/jimmunol/190.5.1899
Brief Reviews
Molecular Basis of DNA Recognition in the Immune System
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 1911–1918, https://doi.org/10.4049/jimmunol.1203162
Cutting Edge
Cutting Edge: An Inactive Chromatin Configuration at the IL-10 Locus in Human Neutrophils
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 1921–1925, https://doi.org/10.4049/jimmunol.1203022
Antigen Recognition and Responses
Kidins220/ARMS Associates with B-Raf and the TCR, Promoting Sustained Erk Signaling in T Cells
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 1927–1935, https://doi.org/10.4049/jimmunol.1200653
CD8α+ Dendritic Cell Trans Presentation of IL-15 to Naive CD8+ T Cells Produces Antigen-Inexperienced T Cells in the Periphery with Memory Phenotype and Function
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 1936–1947, https://doi.org/10.4049/jimmunol.1203149
Autoimmunity
Activated Invariant NKT Cells Control Central Nervous System Autoimmunity in a Mechanism That Involves Myeloid-Derived Suppressor Cells
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 1948–1960, https://doi.org/10.4049/jimmunol.1201718
Antagonizing the α4β1 Integrin, but Not α4β7, Inhibits Leukocytic Infiltration of the Central Nervous System in Rhesus Monkey Experimental Autoimmune Encephalomyelitis
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 1961–1973, https://doi.org/10.4049/jimmunol.1202490
Rheumatoid Factor B Cell Memory Leads to Rapid, Switched Antibody-Forming Cell Responses
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 1974–1981, https://doi.org/10.4049/jimmunol.1202816
Immune Regulation
Differential Ly49e Expression Pathways in Resting versus TCR-Activated Intraepithelial γδ T Cells
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 1982–1990, https://doi.org/10.4049/jimmunol.1200354
Sustained and Incomplete Recovery of Naive CD8+ T Cell Precursors after Sepsis Contributes to Impaired CD8+ T Cell Responses to Infection
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 1991–2000, https://doi.org/10.4049/jimmunol.1202379
Helios+ and Helios− Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2001–2008, https://doi.org/10.4049/jimmunol.1201379
Hepatic Stellate Cells Preferentially Induce Foxp3+ Regulatory T Cells by Production of Retinoic Acid
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2009–2016, https://doi.org/10.4049/jimmunol.1201937
Spatial Coupling of JNK Activation to the B Cell Antigen Receptor by Tyrosine-Phosphorylated Ezrin
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2017–2026, https://doi.org/10.4049/jimmunol.1201292
Butyrophilin-like 2 Modulates B7 Costimulation To Induce Foxp3 Expression and Regulatory T Cell Development in Mature T Cells
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2027–2035, https://doi.org/10.4049/jimmunol.1201760
Constitutive Lymphocyte Transmigration across the Basal Lamina of High Endothelial Venules Is Regulated by the Autotaxin/Lysophosphatidic Acid Axis
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2036–2048, https://doi.org/10.4049/jimmunol.1202025
Tissue-Specific Host Recognition by Complement Factor H Is Mediated by Differential Activities of Its Glycosaminoglycan-Binding Regions
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2049–2057, https://doi.org/10.4049/jimmunol.1201751
Usage of Sphingosine Kinase Isoforms in Mast Cells Is Species and/or Cell Type Determined
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2058–2067, https://doi.org/10.4049/jimmunol.1201503
T Cell Ig Mucin-3 Promotes Homeostasis of Sepsis by Negatively Regulating the TLR Response
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2068–2079, https://doi.org/10.4049/jimmunol.1202661
Immune System Development
Sox4 Is Required for the Survival of Pro-B Cells
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2080–2089, https://doi.org/10.4049/jimmunol.1202736
Studies of Lymphocyte Reconstitution in a Humanized Mouse Model Reveal a Requirement of T Cells for Human B Cell Maturation
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2090–2101, https://doi.org/10.4049/jimmunol.1202810
Analysis of APC Types Involved in CD4 Tolerance and Regulatory T Cell Generation Using Reaggregated Thymic Organ Cultures
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2102–2110, https://doi.org/10.4049/jimmunol.1202883
Porcine γδ T Lymphocytes Can Be Categorized into Two Functionally and Developmentally Distinct Subsets according to Expression of CD2 and Level of TCR
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2111–2120, https://doi.org/10.4049/jimmunol.1202890
A Role for Ly108 in the Induction of Promyelocytic Zinc Finger Transcription Factor in Developing Thymocytes
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2121–2128, https://doi.org/10.4049/jimmunol.1202145
Immunogenetics
A Bacterial Artificial Chromosome Transgene with Polymorphic Cd72 Inhibits the Development of Glomerulonephritis and Vasculitis in MRL-Faslpr Lupus Mice
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2129–2137, https://doi.org/10.4049/jimmunol.1202196
Immunotherapy and Vaccines
Live Attenuated Leishmania donovani p27 Gene Knockout Parasites Are Nonpathogenic and Elicit Long-Term Protective Immunity in BALB/c Mice
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2138–2149, https://doi.org/10.4049/jimmunol.1202801
Infectious Disease and Host Response
Temporal Dynamics of the Primary Human T Cell Response to Yellow Fever Virus 17D As It Matures from an Effector- to a Memory-Type Response
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2150–2158, https://doi.org/10.4049/jimmunol.1202234
Targeting Macrophage Activation for the Prevention and Treatment of Staphylococcus aureus Biofilm Infections
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2159–2168, https://doi.org/10.4049/jimmunol.1202348
Addition of Glycosylation to Influenza A Virus Hemagglutinin Modulates Antibody-Mediated Recognition of H1N1 2009 Pandemic Viruses
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2169–2177, https://doi.org/10.4049/jimmunol.1202433
Critical Role for All-trans Retinoic Acid for Optimal Effector and Effector Memory CD8 T Cell Differentiation
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2178–2187, https://doi.org/10.4049/jimmunol.1201945
Virus-Encoded TLR Ligands Reveal Divergent Functional Responses of Mononuclear Phagocytes in Pathogenic Simian Immunodeficiency Virus Infection
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2188–2198, https://doi.org/10.4049/jimmunol.1201645
IL-2 Produced by CD8+ Immune T Cells Can Augment Their IFN-γ Production Independently from Their Proliferation in the Secondary Response to an Intracellular Pathogen
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2199–2207, https://doi.org/10.4049/jimmunol.1202256
Innate Immunity and Inflammation
Fer Kinase Limits Neutrophil Chemotaxis toward End Target Chemoattractants
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2208–2216, https://doi.org/10.4049/jimmunol.1200322
TRIF-Mediated TLR3 and TLR4 Signaling Is Negatively Regulated by ADAM15
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2217–2228, https://doi.org/10.4049/jimmunol.1201630
Distinct Populations of Innate CD8+ T Cells Revealed in a CXCR3 Reporter Mouse
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2229–2240, https://doi.org/10.4049/jimmunol.1201170
IFN-γ Production by Amyloid β–Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer’s Disease
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2241–2251, https://doi.org/10.4049/jimmunol.1200947
Keratinocyte Overexpression of IL-17C Promotes Psoriasiform Skin Inflammation
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2252–2262, https://doi.org/10.4049/jimmunol.1201505
Inhibition of TLR4 Signaling by TRAM-Derived Decoy Peptides In Vitro and In Vivo
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2263–2272, https://doi.org/10.4049/jimmunol.1202703
Vitronectin Inhibits Efferocytosis through Interactions with Apoptotic Cells as well as with Macrophages
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2273–2281, https://doi.org/10.4049/jimmunol.1200625
Activation of Invariant NK T Cells in Periodontitis Lesions
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2282–2291, https://doi.org/10.4049/jimmunol.1201215
Resistin-like Molecule α Promotes Pathogenic Th17 Cell Responses and Bacterial-Induced Intestinal Inflammation
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2292–2300, https://doi.org/10.4049/jimmunol.1200706
Serotonin Skews Human Macrophage Polarization through HTR2B and HTR7
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2301–2310, https://doi.org/10.4049/jimmunol.1201133
Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2311–2319, https://doi.org/10.4049/jimmunol.1202749
Molecular and Structural Immunology
Crystal Structure of IL-17 Receptor B SEFIR Domain
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2320–2326, https://doi.org/10.4049/jimmunol.1202922
Computational Identification of Antigen-Binding Antibody Fragments
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2327–2334, https://doi.org/10.4049/jimmunol.1200757
Two Rare Disease-Associated Tyk2 Variants Are Catalytically Impaired but Signaling Competent
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2335–2344, https://doi.org/10.4049/jimmunol.1203118
NFATc1 Induction in Peripheral T and B Lymphocytes
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2345–2353, https://doi.org/10.4049/jimmunol.1201591
Mucosal Immunology
Immunopathology of Immune Reconstitution Inflammatory Syndrome in Whipple’s Disease
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2354–2361, https://doi.org/10.4049/jimmunol.1202171
FcαRI-Mediated Inhibition of IL-12 Production and Priming by IFN-γ of Human Monocytes and Dendritic Cells
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2362–2371, https://doi.org/10.4049/jimmunol.1201128
Transplantation
Prostaglandin E2 Potentiates Mesenchymal Stem Cell–Induced IL-10+IFN-γ+CD4+ Regulatory T Cells To Control Transplant Arteriosclerosis
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2372–2380, https://doi.org/10.4049/jimmunol.1202996
Tumor Immunology
Human NK Cells Selective Targeting of Colon Cancer–Initiating Cells: A Role for Natural Cytotoxicity Receptors and MHC Class I Molecules
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2381–2390, https://doi.org/10.4049/jimmunol.1201542
Plasmacytoid Dendritic Cells Play a Key Role in Tumor Progression in Lipopolysaccharide-Stimulated Lung Tumor–Bearing Mice
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2391–2402, https://doi.org/10.4049/jimmunol.1202086
Tumor-Derived γδ Regulatory T Cells Suppress Innate and Adaptive Immunity through the Induction of Immunosenescence
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2403–2414, https://doi.org/10.4049/jimmunol.1202369
Tumor-Derived IL-35 Promotes Tumor Growth by Enhancing Myeloid Cell Accumulation and Angiogenesis
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2415–2423, https://doi.org/10.4049/jimmunol.1202535
Peripheral Blood NK Cells from Breast Cancer Patients Are Tumor-Induced Composite Subsets
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2424–2436, https://doi.org/10.4049/jimmunol.1200140
Multiple Tumor-Associated MicroRNAs Modulate the Survival and Longevity of Dendritic Cells by Targeting YWHAZ and Bcl2 Signaling Pathways
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2437–2446, https://doi.org/10.4049/jimmunol.1202282
Cigarette Smoke Exposure Inhibits Contact Hypersensitivity via the Generation of Platelet-Activating Factor Agonists
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2447–2454, https://doi.org/10.4049/jimmunol.1202699
Mouse Tumor Vasculature Expresses NKG2D Ligands and Can Be Targeted by Chimeric NKG2D-Modified T Cells
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2455–2463, https://doi.org/10.4049/jimmunol.1201314
Antitumor Effect of Paclitaxel Is Mediated by Inhibition of Myeloid-Derived Suppressor Cells and Chronic Inflammation in the Spontaneous Melanoma Model
The Journal of Immunology, Volume 190, Issue 5, March 2013, Pages 2464–2471, https://doi.org/10.4049/jimmunol.1202781
