Volume 189, Issue 8
October 2012
Cover image
Cover image
On the cover: Toluidine blue-stained section of a knee joint of a mouse showing complete recovery from collagen-induced arthritis upon treatment with SB1578, a novel JAK2 inhibitor. Madan, B., K. C. Goh, S. Hart, A. D. William, R. Jayaraman, K. Ethirajulu, B. W. Dymock, and J. M. Wood. 2012. SB1578, a novel inhibitor of JAK2, FLT3, and c-Fms for the treatment of rheumatoid arthritis. J. Immunol. 189: 4123–4134.
ISSN 0022-1767
EISSN 1550-6606
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Volume 189, Issue 8, October 2012
In Memoriam
Byron H. Waksman, M.D. (AAI ’50) 1919–2012
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3783–3784, https://doi.org/10.4049/jimmunol.1290059
In This Issue
In This Issue
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3785–3786, https://doi.org/10.4049/jimmunol.1290061
Letters to the Editor
Comment on “Human Antitumor CD8+ T Cells Producing Th1 Polycytokines Show Superior Antigen Sensitivity and Tumor Recognition”
The Journal of Immunology, Volume 189, Issue 8, October 2012, Page 3787, https://doi.org/10.4049/jimmunol.1290057
Response to Comment on “Human Antitumor CD8+ T Cells Producing Th1 Polycytokines Show Superior Antigen Sensitivity and Tumor Recognition”
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3787–3788, https://doi.org/10.4049/jimmunol.1290058
Translating Immunology
IFN-α in the Treatment of Melanoma
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3789–3793, https://doi.org/10.4049/jimmunol.1290060
Cutting Edge
Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1β Production
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3795–3799, https://doi.org/10.4049/jimmunol.1200312
Cutting Edge: NADPH Oxidase Modulates MHC Class II Antigen Presentation by B Cells
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3800–3804, https://doi.org/10.4049/jimmunol.1103080
Cellular Immunology and Immune Regulation
Prevention of Virus-Induced Type 1 Diabetes with Antibiotic Therapy
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3805–3814, https://doi.org/10.4049/jimmunol.1201257
Kruppel-like Factor 2 Modulates CCR5 Expression and Susceptibility to HIV-1 Infection
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3815–3821, https://doi.org/10.4049/jimmunol.1201431
Inhibitors of DNA Binding Proteins Restrict T Cell Potential by Repressing Notch1 Expression in Flt3-Negative Common Lymphoid Progenitors
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3822–3830, https://doi.org/10.4049/jimmunol.1103723
The Thymic Niche Does Not Limit Development of the Naturally Diverse Population of Mouse Regulatory T Lymphocytes
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3831–3837, https://doi.org/10.4049/jimmunol.1201564
Increased Memory Differentiation Is Associated with Decreased Polyfunctionality for HIV but Not for Cytomegalovirus-Specific CD8+ T Cells
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3838–3847, https://doi.org/10.4049/jimmunol.1201488
Hepatic Stellate Cells Undermine the Allostimulatory Function of Liver Myeloid Dendritic Cells via STAT3-Dependent Induction of IDO
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3848–3858, https://doi.org/10.4049/jimmunol.1200819
Receptor Cross-Talk Spatially Restricts p-ERK during TLR4 Stimulation of Autoreactive B Cells
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3859–3868, https://doi.org/10.4049/jimmunol.1200940
CD11c+ Cells Are Required for Antigen-Induced Increase of Mast Cells in the Lung
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3869–3877, https://doi.org/10.4049/jimmunol.1201200
Dendritic Cell-Specific Disruption of TGF-β Receptor II Leads to Altered Regulatory T Cell Phenotype and Spontaneous Multiorgan Autoimmunity
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3878–3893, https://doi.org/10.4049/jimmunol.1201029
MicroRNAs Control the Maintenance of Thymic Epithelia and Their Competence for T Lineage Commitment and Thymocyte Selection
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3894–3904, https://doi.org/10.4049/jimmunol.1200783
Role of Macrophage Migration Inhibitory Factor in the Regulatory T Cell Response of Tumor-Bearing Mice
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3905–3913, https://doi.org/10.4049/jimmunol.1102152
Autotaxin through Lysophosphatidic Acid Stimulates Polarization, Motility, and Transendothelial Migration of Naive T Cells
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3914–3924, https://doi.org/10.4049/jimmunol.1201604
IL-10–Producing Regulatory B Cells in the Pathogenesis of Chronic Hepatitis B Virus Infection
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3925–3935, https://doi.org/10.4049/jimmunol.1103139
Cell-Intrinsic Abrogation of TGF-β Signaling Delays but Does Not Prevent Dysfunction of Self/Tumor-Specific CD8 T Cells in a Murine Model of Autochthonous Prostate Cancer
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3936–3946, https://doi.org/10.4049/jimmunol.1201415
Foxp3 Expression Is Required for the Induction of Therapeutic Tissue Tolerance
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3947–3956, https://doi.org/10.4049/jimmunol.1200449
Molecular and Structural Immunology
Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3957–3969, https://doi.org/10.4049/jimmunol.1201736
Target DNA Sequence Directly Regulates the Frequency of Activation-Induced Deaminase-Dependent Mutations
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3970–3982, https://doi.org/10.4049/jimmunol.1200416
HLA-DM Constrains Epitope Selection in the Human CD4 T Cell Response to Vaccinia Virus by Favoring the Presentation of Peptides with Longer HLA-DM–Mediated Half-Lives
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3983–3994, https://doi.org/10.4049/jimmunol.1200626
Extensive Diversification of IgD-, IgY-, and Truncated IgY(ΔFc)-Encoding Genes in the Red-Eared Turtle (Trachemys scripta elegans)
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 3995–4004, https://doi.org/10.4049/jimmunol.1200188
The Importance of the Erk Pathway in the Development of Linker for Activation of T Cells-Mediated Autoimmunity
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 4005–4013, https://doi.org/10.4049/jimmunol.1201380
Immunogenetics
Chronic Beryllium Disease, HLA-DPB1, and the DP Peptide Binding Groove
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 4014–4023, https://doi.org/10.4049/jimmunol.1200798
Scavenger Receptor in Fish Is a Lipopolysaccharide Recognition Molecule Involved in Negative Regulation of NF-κB Activation by Competing with TNF Receptor-Associated Factor 2 Recruitment into the TNF-α Signaling Pathway
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 4024–4039, https://doi.org/10.4049/jimmunol.1201244
Host Defense
Staphylococcus aureus Induces Type I IFN Signaling in Dendritic Cells Via TLR9
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 4040–4046, https://doi.org/10.4049/jimmunol.1201055
Genetic Ablation of Arginase 1 in Macrophages and Neutrophils Enhances Clearance of an Arthritogenic Alphavirus
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 4047–4059, https://doi.org/10.4049/jimmunol.1201240
Protective Immunity against Pulmonary Cryptococcosis Is Associated with STAT1-Mediated Classical Macrophage Activation
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 4060–4068, https://doi.org/10.4049/jimmunol.1103455
Abelson Tyrosine Kinase Controls Phagosomal Acidification Required for Killing of Mycobacterium tuberculosis in Human Macrophages
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 4069–4078, https://doi.org/10.4049/jimmunol.1201538
Blockade of IL-10 Signaling during Bacillus Calmette-Guérin Vaccination Enhances and Sustains Th1, Th17, and Innate Lymphoid IFN-γ and IL-17 Responses and Increases Protection to Mycobacterium tuberculosis Infection
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 4079–4087, https://doi.org/10.4049/jimmunol.1201061
IFN-α and Lipopolysaccharide Upregulate APOBEC3 mRNA through Different Signaling Pathways
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 4088–4103, https://doi.org/10.4049/jimmunol.1200777
Inflammation
CD31 Exhibits Multiple Roles in Regulating T Lymphocyte Trafficking In Vivo
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 4104–4111, https://doi.org/10.4049/jimmunol.1201739
ATP Induces Protein Arginine Deiminase 2-Dependent Citrullination in Mast Cells through the P2X7 Purinergic Receptor
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 4112–4122, https://doi.org/10.4049/jimmunol.1201098
SB1578, a Novel Inhibitor of JAK2, FLT3, and c-Fms for the Treatment of Rheumatoid Arthritis
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 4123–4134, https://doi.org/10.4049/jimmunol.1200675
Control of Allergen-Induced Inflammation and Hyperresponsiveness by the Metalloproteinase ADAMTS-12
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 4135–4143, https://doi.org/10.4049/jimmunol.1103739
Autophagy Regulates IL-23 Secretion and Innate T Cell Responses through Effects on IL-1 Secretion
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 4144–4153, https://doi.org/10.4049/jimmunol.1201946
Regulation of Inflammatory Response by 3-Methyladenine Involves the Coordinative Actions on Akt and Glycogen Synthase Kinase 3β Rather than Autophagy
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 4154–4164, https://doi.org/10.4049/jimmunol.1102739
B7x in the Periphery Abrogates Pancreas-Specific Damage Mediated by Self-reactive CD8 T Cells
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 4165–4174, https://doi.org/10.4049/jimmunol.1201241
NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 4175–4181, https://doi.org/10.4049/jimmunol.1201516
Clinical Immunology
Immunoproteasome Subunit LMP7 Deficiency and Inhibition Suppresses Th1 and Th17 but Enhances Regulatory T Cell Differentiation
The Journal of Immunology, Volume 189, Issue 8, October 2012, Pages 4182–4193, https://doi.org/10.4049/jimmunol.1201183
Corrections
Correction: Structural and Functional Characterization of a Novel Nonglycosidic Type I NKT Agonist with Immunomodulatory Properties
The Journal of Immunology, Volume 189, Issue 8, October 2012, Page 4194, https://doi.org/10.4049/jimmunol.1290056
