Volume 186, Issue 1
January 2011
Cover image
Cover image
On the cover: Epigenetic immune lineage analysis. DNA extracted from CD4+ T lymphocytes is subjected to bisulphite conversion and PCR amplified with primers targeting the IL-17, IFNG, FOXP3 and IL-13 loci. Methylation status, and thus lineage commitment towards Th1, Th2, Th17, and regulatory T cells, is subsequently determined using methyl-sensitive single-nucleotide primer extension. Janson, P. C. J., L. B. Linton, E. Ahlén Bergman, P. Marits, M. Eberhardson, F. Piehl, V. Malmström, and O. Winqvist. 2011. Profiling of CD4+ T cells with epigenetic immune lineage analysis. J. Immunol. 186: 92–102.
ISSN 0022-1767
EISSN 1550-6606
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Volume 186, Issue 1, January 2011
In this Issue
In This Issue
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 1–2, https://doi.org/10.4049/jimmunol.1090114
Letters to the Editor
Comment on “Regulatory T Cells Protect from Local and Systemic Bone Destruction in Arthritis”
The Journal of Immunology, Volume 186, Issue 1, January 2011, Page 3, https://doi.org/10.4049/jimmunol.1090115
Response to Comment on “Regulatory T Cells Protect from Local and Systemic Bone Destruction in Arthritis”
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 3–4, https://doi.org/10.4049/jimmunol.1090116
Comment on “Conventional B2 B Cell Depletion Ameliorates whereas Its Adoptive Transfer Aggravates Atherosclerosis”
The Journal of Immunology, Volume 186, Issue 1, January 2011, Page 4, https://doi.org/10.4049/jimmunol.1090119
Response to Comment on “Conventional B2 B Cell Depletion Ameliorates whereas Its Adoptive Transfer Aggravates Atherosclerosis”
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 4–5, https://doi.org/10.4049/jimmunol.1090120
Pillars of Immunology
Altered Peptide Ligands Make Their Entry
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 7–8, https://doi.org/10.4049/jimmunol.1090118
Pillars Article: Separation of IL-4 Production from Th Cell Proliferation by an Altered T Cell Receptor Ligand. Science. 1991. 252: 1308–1310
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 9–11, https://doi.org/10.1093/jimmunol/186.1.9
Brief Reviews
The Role of Osteoclast-Associated Receptor in Osteoimmunology
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 13–18, https://doi.org/10.4049/jimmunol.1002483
Cutting Edge
Cutting Edge: Critical Role of Intracellular Osteopontin in Antifungal Innate Immune Responses
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 19–23, https://doi.org/10.4049/jimmunol.1002735
Cellular Immunology and Immune Regulation
Mast Cell-Derived IL-10 Suppresses Germinal Center Formation by Affecting T Follicular Helper Cell Function
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 25–31, https://doi.org/10.4049/jimmunol.1001657
The Influence of Excessive IL-6 Production In Vivo on the Development and Function of Foxp3+ Regulatory T Cells
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 32–40, https://doi.org/10.4049/jimmunol.0903314
CD8+CD122+ Regulatory T Cells (Tregs) and CD4+ Tregs Cooperatively Prevent and Cure CD4+ Cell-Induced Colitis
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 41–52, https://doi.org/10.4049/jimmunol.1000800
Dendritic Cells Distinguish Individual Chemokine Signals through CCR7 and CXCR4
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 53–61, https://doi.org/10.4049/jimmunol.1002358
Interactions of NK Cell Receptor KIR3DL1*004 with Chaperones and Conformation-Specific Antibody Reveal a Functional Folded State As Well As Predominant Intracellular Retention
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 62–72, https://doi.org/10.4049/jimmunol.0903657
Exosomes Containing Glycoprotein 350 Released by EBV-Transformed B Cells Selectively Target B Cells through CD21 and Block EBV Infection In Vitro
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 73–82, https://doi.org/10.4049/jimmunol.1001145
IL-9 Production by Regulatory T Cells Recruits Mast Cells That Are Essential for Regulatory T Cell-Induced Immune Suppression
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 83–91, https://doi.org/10.4049/jimmunol.1001183
Profiling of CD4+ T Cells with Epigenetic Immune Lineage Analysis
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 92–102, https://doi.org/10.4049/jimmunol.1000960
Glucocorticosteroids Modify Langerhans Cells To Produce TGF-β and Expand Regulatory T Cells
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 103–112, https://doi.org/10.4049/jimmunol.1002485
CD8 Regulates T Regulatory Cell Production of IL-6 and Maintains Their Suppressive Phenotype in Allergic Lung Disease
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 113–120, https://doi.org/10.4049/jimmunol.1001663
Targeting the CXCR4–CXCL12 Axis Mobilizes Autologous Hematopoietic Stem Cells and Prolongs Islet Allograft Survival via Programmed Death Ligand 1
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 121–131, https://doi.org/10.4049/jimmunol.1000799
The Vitamin D Analog, TX527, Promotes a Human CD4+CD25highCD127low Regulatory T Cell Profile and Induces a Migratory Signature Specific for Homing to Sites of Inflammation
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 132–142, https://doi.org/10.4049/jimmunol.1000695
TNF Receptor-Associated Factor 3 Is Required for T Cell-Mediated Immunity and TCR/CD28 Signaling
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 143–155, https://doi.org/10.4049/jimmunol.1000290
A Major Role for Bim in Regulatory T Cell Homeostasis
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 156–163, https://doi.org/10.4049/jimmunol.1001505
H5N1 Virus Activates Signaling Pathways in Human Endothelial Cells Resulting in a Specific Imbalanced Inflammatory Response
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 164–173, https://doi.org/10.4049/jimmunol.0904170
A Role for IL-15 in the Migration of Effector CD8 T Cells to the Lung Airways following Influenza Infection
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 174–182, https://doi.org/10.4049/jimmunol.1002613
A Marked Reduction in Priming of Cytotoxic CD8+ T Cells Mediated by Stress-Induced Glucocorticoids Involves Multiple Deficiencies in Cross-Presentation by Dendritic Cells
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 183–194, https://doi.org/10.4049/jimmunol.1001737
Sepsis Induces Early Alterations in Innate Immunity That Impact Mortality to Secondary Infection
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 195–202, https://doi.org/10.4049/jimmunol.1002104
FADD Deficiency Impairs Early Hematopoiesis in the Bone Marrow
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 203–213, https://doi.org/10.4049/jimmunol.1000648
Alloantibodies Prevent the Induction of Transplantation Tolerance by Enhancing Alloreactive T Cell Priming
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 214–221, https://doi.org/10.4049/jimmunol.1001172
Distinct Roles for the NK Cell-Activating Receptors in Mediating Interactions with Dendritic Cells and Tumor Cells
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 222–229, https://doi.org/10.4049/jimmunol.1002597
Graft-versus-Host Disease Is Independent of Innate Signaling Pathways Triggered by Pathogens in Host Hematopoietic Cells
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 230–241, https://doi.org/10.4049/jimmunol.1002965
Sequential Binding of αvβ3 and ICAM-1 Determines Fibrin-Mediated Melanoma Capture and Stable Adhesion to CD11b/CD18 on Neutrophils
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 242–254, https://doi.org/10.4049/jimmunol.1000494
Bcl6 Is Required for the Development of Mouse CD4+ and CD8α+ Dendritic Cells
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 255–263, https://doi.org/10.4049/jimmunol.0903714
Inhibition of Tumor-Induced Myeloid-Derived Suppressor Cell Function by a Nanoparticulated Adjuvant
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 264–274, https://doi.org/10.4049/jimmunol.1001465
Stimulation of the Glucocorticoid-Induced TNF Receptor Family-Related Receptor on CD8 T Cells Induces Protective and High-Avidity T Cell Responses to Tumor-Specific Antigens
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 275–283, https://doi.org/10.4049/jimmunol.1001308
The TLR7 Agonist R848 Alleviates Allergic Inflammation by Targeting Invariant NKT Cells To Produce IFN-γ
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 284–290, https://doi.org/10.4049/jimmunol.1001348
Enhancement of Suboptimal CD8 Cytotoxic T Cell Effector Function In Vivo Using Antigen-Specific CD80 Defective T Cells
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 291–304, https://doi.org/10.4049/jimmunol.0902370
Endogenous Cortisol and TGF-β in Human Aqueous Humor Contribute to Ocular Immune Privilege by Regulating Dendritic Cell Function
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 305–311, https://doi.org/10.4049/jimmunol.1001450
Epitope Hierarchy of Spontaneous CD4+ T Cell Responses to LAGE-1
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 312–322, https://doi.org/10.4049/jimmunol.1001989
SHIP Represses Th2 Skewing by Inhibiting IL-4 Production from Basophils
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 323–332, https://doi.org/10.4049/jimmunol.1002778
Molecular and Structural Immunology
Carbohydrates Contribute to the Interactions between Cockroach Allergen Bla g 2 and a Monoclonal Antibody
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 333–340, https://doi.org/10.4049/jimmunol.1002318
Molecular and Functional Characterization of Cynomolgus Monkey IgG Subclasses
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 341–349, https://doi.org/10.4049/jimmunol.1001685
The Role of Germline Promoters and I Exons in Cytokine-Induced Gene-Specific Class Switch Recombination
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 350–358, https://doi.org/10.4049/jimmunol.1003108
Immunogenetics
Persistent Survival of Prevalent Clonotypes within an Immunodominant HIV Gag-Specific CD8+ T Cell Response
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 359–371, https://doi.org/10.4049/jimmunol.1001807
Remarkable Conservation of Distinct Nonclassical MHC Class I Lineages in Divergent Amphibian Species
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 372–381, https://doi.org/10.4049/jimmunol.1001467
H2 Control of Natural T Regulatory Cell Frequency in the Lymph Node Correlates with Susceptibility to Day 3 Thymectomy-Induced Autoimmune Disease
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 382–389, https://doi.org/10.4049/jimmunol.1002110
Host Defense
Murine FLT3 Ligand-Derived Dendritic Cell-Mediated Early Immune Responses Are Critical to Controlling Cell-Free Human T Cell Leukemia Virus Type 1 Infection
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 390–402, https://doi.org/10.4049/jimmunol.1002570
Neutrophils Activate Alveolar Macrophages by Producing Caspase-6–Mediated Cleavage of IL-1 Receptor-Associated Kinase-M
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 403–410, https://doi.org/10.4049/jimmunol.1001906
Leishmania Inhibitor of Serine Peptidase 2 Prevents TLR4 Activation by Neutrophil Elastase Promoting Parasite Survival in Murine Macrophages
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 411–422, https://doi.org/10.4049/jimmunol.1002175
Protective Roles of CX3CR1-Mediated Signals in Toxin A-Induced Enteritis through the Induction of Heme Oxygenase-1 Expression
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 423–431, https://doi.org/10.4049/jimmunol.1000043
CD8+ Cells Enhance Resistance to Pulmonary Serotype 3 Streptococcus pneumoniae Infection in Mice
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 432–442, https://doi.org/10.4049/jimmunol.1001963
T and B Cells Are Not Required for Clearing Staphylococcus aureus in Systemic Infection Despite a Strong TLR2–MyD88-Dependent T Cell Activation
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 443–452, https://doi.org/10.4049/jimmunol.1001407
Hypoxia Selectively Inhibits Respiratory Burst Activity and Killing of Staphylococcus aureus in Human Neutrophils
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 453–463, https://doi.org/10.4049/jimmunol.1002213
β5 Integrin Is the Major Contributor to the αv Integrin-Mediated Blockade of HIV-1 Replication
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 464–470, https://doi.org/10.4049/jimmunol.1002693
Chemokine Receptor Ccr2 Is Critical for Monocyte Accumulation and Survival in West Nile Virus Encephalitis
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 471–478, https://doi.org/10.4049/jimmunol.1003003
HIV Immune Escape at an Immunodominant Epitope in HLA-B*27–Positive Individuals Predicts Viral Load Outcome
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 479–488, https://doi.org/10.4049/jimmunol.0903227
Nonconventional CD8+ T Cell Responses to Listeria Infection in Mice Lacking MHC Class Ia and H2-M3
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 489–498, https://doi.org/10.4049/jimmunol.1002639
Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 499–507, https://doi.org/10.4049/jimmunol.0903534
Inflammation
CCR2-Antagonist Prophylaxis Reduces Pulmonary Immune Pathology and Markedly Improves Survival during Influenza Infection
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 508–515, https://doi.org/10.4049/jimmunol.1001002
Chemoattractant-Induced Signaling via the Ras–ERK and PI3K–Akt Networks, along with Leukotriene C4 Release, Is Dependent on the Tyrosine Kinase Lyn in IL-5– and IL-3–Primed Human Blood Eosinophils
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 516–526, https://doi.org/10.4049/jimmunol.1000955
A Small-Molecule Macrophage Migration Inhibitory Factor Antagonist Protects against Glomerulonephritis in Lupus-Prone NZB/NZW F1 and MRL/lpr Mice
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 527–538, https://doi.org/10.4049/jimmunol.1001767
Negative Feedback Regulation of NF-κB Action by CITED2 in the Nucleus
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 539–548, https://doi.org/10.4049/jimmunol.1001650
Netrin-1 Signaling Dampens Inflammatory Peritonitis
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 549–555, https://doi.org/10.4049/jimmunol.1002671
TLR4 through IFN-β Promotes Low Molecular Mass Hyaluronan-Induced Neutrophil Apoptosis
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 556–562, https://doi.org/10.4049/jimmunol.1001630
EC144, a Synthetic Inhibitor of Heat Shock Protein 90, Blocks Innate and Adaptive Immune Responses in Models of Inflammation and Autoimmunity
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 563–575, https://doi.org/10.4049/jimmunol.1000222
5A, an Apolipoprotein A-I Mimetic Peptide, Attenuates the Induction of House Dust Mite-Induced Asthma
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 576–583, https://doi.org/10.4049/jimmunol.1001534
Antiplatelet Activity of Valproic Acid Contributes to Decreased Soluble CD40 Ligand Production in HIV Type 1-Infected Individuals
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 584–591, https://doi.org/10.4049/jimmunol.1001911
Casein α s1 Is Expressed by Human Monocytes and Upregulates the Production of GM-CSF via p38 MAPK
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 592–601, https://doi.org/10.4049/jimmunol.1001461
Critical Modifier Role of Membrane-Cystic Fibrosis Transmembrane Conductance Regulator-Dependent Ceramide Signaling in Lung Injury and Emphysema
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 602–613, https://doi.org/10.4049/jimmunol.1002850
Clinical Immunology
Acquisition of Humoral Transplantation Tolerance upon De Novo Emergence of B Lymphocytes
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 614–620, https://doi.org/10.4049/jimmunol.1002873
Autoimmune Kidney Disease and Impaired Engulfment of Apoptotic Cells in Mice with Macrophage Peroxisome Proliferator-Activated Receptor γ or Retinoid X Receptor α Deficiency
The Journal of Immunology, Volume 186, Issue 1, January 2011, Pages 621–631, https://doi.org/10.4049/jimmunol.1002230
Corrections
Correction: Smad2 and Smad3 Are Redundantly Essential for the TGF-β–Mediated Regulation of Regulatory T Plasticity and Th1 Development
The Journal of Immunology, Volume 186, Issue 1, January 2011, Page 632, https://doi.org/10.4049/jimmunol.1090121
