Volume 178, Issue 2
January 2007
Cover image
Cover image
On the cover: CFSE-dilution profile of adoptively transferred OT-II T cells from the inguinal lymph node of C57BL/6 recipient mice after OVA immunization in the presence of a catalytic antioxidant. Profile confirms that redox modulation did not affect in vivo T cell expansion, but dramatically inhibited adaptive immune effector function. Tse, H. M., M. J. Milton, S. Schreiner, J. L. Profozich, M. Trucco, and J. D. Piganelli. 2007. Disruption of innate-mediated proinflammatory cytokine and reactive oxygen species third signal leads to antigen-specific hyporesponsiveness. J. Immunol. 178: 908–917.
ISSN 0022-1767
EISSN 1550-6606
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Volume 178, Issue 2, January 2007
In this Issue
In This Issue
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 639–640, https://doi.org/10.4049/jimmunol.178.2.639
Brief Reviews
Arachidonic Acid Metabolism as a Potential Mediator of Cardiac Fibrosis Associated with Inflammation
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 641–646, https://doi.org/10.4049/jimmunol.178.2.641
Cutting Edge
Cutting Edge: KIR3DS1, a Gene Implicated in Resistance to Progression to AIDS, Encodes a DAP12-Associated Receptor Expressed on NK Cells That Triggers NK Cell Activation
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 647–651, https://doi.org/10.4049/jimmunol.178.2.647
Cutting Edge: Distinct NK Receptor Profiles Are Imprinted on CD8 T Cells in the Mucosa and Periphery during the Same Antigen Challenge: Role of Tissue-Specific Factors
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 652–656, https://doi.org/10.4049/jimmunol.178.2.652
Cellular Immunology and Immune Regulation
The Varicellovirus-Encoded TAP Inhibitor UL49.5 Regulates the Presentation of CTL Epitopes by Qa-1b1
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 657–662, https://doi.org/10.4049/jimmunol.178.2.657
Augmented Lipopolysaccharide-Induced TNF-α Production by Peritoneal Macrophages in Type 2 Diabetic Mice Is Dependent on Elevated Glucose and Requires p38 MAPK
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 663–670, https://doi.org/10.4049/jimmunol.178.2.663
A Costimulatory Function for T Cell CD40
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 671–682, https://doi.org/10.4049/jimmunol.178.2.671
TCR Activation Eliminates Glutamate Receptor GluR3 from the Cell Surface of Normal Human T Cells, via an Autocrine/Paracrine Granzyme B-Mediated Proteolytic Cleavage
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 683–692, https://doi.org/10.4049/jimmunol.178.2.683
TLR9-Signaling Pathways Are Involved in Kilham Rat Virus-Induced Autoimmune Diabetes in the Biobreeding Diabetes-Resistant Rat
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 693–701, https://doi.org/10.4049/jimmunol.178.2.693
Prostaglandin I2 Analogs Inhibit Proinflammatory Cytokine Production and T Cell Stimulatory Function of Dendritic Cells
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 702–710, https://doi.org/10.4049/jimmunol.178.2.702
Two Groups of Porcine TCRγδ+ Thymocytes Behave and Diverge Differently
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 711–719, https://doi.org/10.4049/jimmunol.178.2.711
Guanosine Inhibits CD40 Receptor Expression and Function Induced by Cytokines and β Amyloid in Mouse Microglia Cells
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 720–731, https://doi.org/10.4049/jimmunol.178.2.720
IL-21 Counteracts the Regulatory T Cell-Mediated Suppression of Human CD4+ T Lymphocytes
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 732–739, https://doi.org/10.4049/jimmunol.178.2.732
B Cell Receptor Signaling Down-Regulates Forkhead Box Transcription Factor Class O 1 mRNA Expression via Phosphatidylinositol 3-Kinase and Bruton’s Tyrosine Kinase
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 740–747, https://doi.org/10.4049/jimmunol.178.2.740
The Extra Domain A from Fibronectin Targets Antigens to TLR4-Expressing Cells and Induces Cytotoxic T Cell Responses In Vivo
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 748–756, https://doi.org/10.4049/jimmunol.178.2.748
Enforced Expression of Bcl-2 Partially Restores Cell Numbers but Not Functions of TCRγδ Intestinal Intraepithelial T Lymphocytes in IL-15-Deficient Mice
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 757–764, https://doi.org/10.4049/jimmunol.178.2.757
Dual Assemblies of an Activating Immune Receptor, MAIR-II, with ITAM-Bearing Adapters DAP12 and FcRγ Chain on Peritoneal Macrophages
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 765–770, https://doi.org/10.4049/jimmunol.178.2.765
Klotho—a Common Link in Physiological and Rheumatoid Arthritis-Related Aging of Human CD4+ Lymphocytes
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 771–777, https://doi.org/10.4049/jimmunol.178.2.771
Chemokine-Guided CD4+ T Cell Help Enhances Generation of IL-6RαhighIL-7Rαhigh Prememory CD8+ T Cells
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 778–787, https://doi.org/10.4049/jimmunol.178.2.778
The Duration of Exposure to HIV Modulates the Breadth and the Magnitude of HIV-Specific Memory CD4+ T Cells
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 788–797, https://doi.org/10.4049/jimmunol.178.2.788
IL-10 Regulation by HIV-Tat in Primary Human Monocytic Cells: Involvement of Calmodulin/Calmodulin-Dependent Protein Kinase-Activated p38 MAPK and Sp-1 and CREB-1 Transcription Factors
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 798–807, https://doi.org/10.4049/jimmunol.178.2.798
The IREM-1 (CD300f) Inhibitory Receptor Associates with the p85α Subunit of Phosphoinositide 3-Kinase
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 808–816, https://doi.org/10.4049/jimmunol.178.2.808
SAP Regulation of Follicular Helper CD4 T Cell Development and Humoral Immunity Is Independent of SLAM and Fyn Kinase
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 817–828, https://doi.org/10.4049/jimmunol.178.2.817
Thymus Medulla Formation and Central Tolerance Are Restored in IKKα−/− Mice That Express an IKKα Transgene in Keratin 5+ Thymic Epithelial Cells
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 829–837, https://doi.org/10.4049/jimmunol.178.2.829
Donor CD8+ T Cells Mediate Graft-versus-Leukemia Activity without Clinical Signs of Graft-versus-Host Disease in Recipients Conditioned with Anti-CD3 Monoclonal Antibody
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 838–850, https://doi.org/10.4049/jimmunol.178.2.838
Intercellular Adhesion Molecule-1 Expression Is Required on Multiple Cell Types for the Development of Experimental Autoimmune Encephalomyelitis
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 851–857, https://doi.org/10.4049/jimmunol.178.2.851
Bone Marrow-Derived Hemopoietic Precursors Commit to the T Cell Lineage Only after Arrival in the Thymic Microenvironment
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 858–868, https://doi.org/10.4049/jimmunol.178.2.858
HIV-1 Trans Activator of Transcription Protein Elicits Mitochondrial Hyperpolarization and Respiratory Deficit, with Dysregulation of Complex IV and Nicotinamide Adenine Dinucleotide Homeostasis in Cortical Neurons
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 869–876, https://doi.org/10.4049/jimmunol.178.2.869
Alteration of the Migratory Behavior of UV-Induced Regulatory T Cells by Tissue-Specific Dendritic Cells
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 877–886, https://doi.org/10.4049/jimmunol.178.2.877
Regulatory T Cells Maintain Long-Term Tolerance to Myelin Basic Protein by Inducing a Novel, Dynamic State of T Cell Tolerance
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 887–896, https://doi.org/10.4049/jimmunol.178.2.887
FcγRIIB Regulates Autoreactive Primary Antibody-Forming Cell, but Not Germinal Center B Cell, Activity
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 897–907, https://doi.org/10.4049/jimmunol.178.2.897
Disruption of Innate-Mediated Proinflammatory Cytokine and Reactive Oxygen Species Third Signal Leads to Antigen-Specific Hyporesponsiveness
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 908–917, https://doi.org/10.4049/jimmunol.178.2.908
Involvement of Regulatory T Cells in the Experimental Autoimmune Encephalomyelitis-Preventive Effect of Dendritic Cells Expressing Myelin Oligodendrocyte Glycoprotein plus TRAIL
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 918–925, https://doi.org/10.4049/jimmunol.178.2.918
Redundancy in B Cell Developmental Pathways: c-Cbl Inactivation Rescues Early B Cell Development through a B Cell Linker Protein-Independent Pathway
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 926–935, https://doi.org/10.4049/jimmunol.178.2.926
Cigarette Smoke Impairs NK Cell-Dependent Tumor Immune Surveillance
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 936–943, https://doi.org/10.4049/jimmunol.178.2.936
Molecular and Structural Immunology
First Glimpse of the Peptide Presentation by Rhesus Macaque MHC Class I: Crystal Structures of Mamu-A*01 Complexed with Two Immunogenic SIV Epitopes and Insights into CTL Escape
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 944–952, https://doi.org/10.4049/jimmunol.178.2.944
Bcl10/Malt1 Signaling Is Essential for TCR-Induced NF-κB Activation in Thymocytes but Dispensable for Positive or Negative Selection
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 953–960, https://doi.org/10.4049/jimmunol.178.2.953
Promoter Region Architecture and Transcriptional Regulation of the Genes for the MHC Class I-Related Chain A and B Ligands of NKG2D
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 961–969, https://doi.org/10.4049/jimmunol.178.2.961
Host Defense
Age-Associated Defect in Human TLR-1/2 Function
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 970–975, https://doi.org/10.4049/jimmunol.178.2.970
CD27low CD4 T Lymphocytes That Accumulate in the Mouse Lungs during Mycobacterial Infection Differentiate from CD27high Precursors In Situ, Produce IFN-γ, and Protect the Host against Tuberculosis Infection
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 976–985, https://doi.org/10.4049/jimmunol.178.2.976
Identification of CXCL11 as a STAT3-Dependent Gene Induced by IFN
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 986–992, https://doi.org/10.4049/jimmunol.178.2.986
Oxidized Phospholipids Inhibit Phagocytosis and Impair Outcome in Gram-Negative Sepsis In Vivo
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 993–1001, https://doi.org/10.4049/jimmunol.178.2.993
lgtC Expression Modulates Resistance to C4b Deposition on an Invasive Nontypeable Haemophilus influenzae
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1002–1012, https://doi.org/10.4049/jimmunol.178.2.1002
Matrix Metalloproteinase 9 Activity Enhances Host Susceptibility to Pulmonary Infection with Type A and B Strains of Francisella tularensis
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1013–1020, https://doi.org/10.4049/jimmunol.178.2.1013
Targeted Antireceptor Therapy with Monoclonal Antibodies Leads to the Formation of Inactivated Tetrameric Forms of ErbB Receptors
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1021–1029, https://doi.org/10.4049/jimmunol.178.2.1021
Priming with Cold-Adapted Influenza A Does Not Prevent Infection but Elicits Long-Lived Protection against Supralethal Challenge with Heterosubtypic Virus
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1030–1038, https://doi.org/10.4049/jimmunol.178.2.1030
Coordinated Control of Immunity to Muscle Stage Trichinella spiralis by IL-10, Regulatory T Cells, and TGF-β
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1039–1047, https://doi.org/10.4049/jimmunol.178.2.1039
Distinct NKT Cell Subsets Are Induced by Different Chlamydia Species Leading to Differential Adaptive Immunity and Host Resistance to the Infections
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1048–1058, https://doi.org/10.4049/jimmunol.178.2.1048
Oral Vaccination with Salmonella Simultaneously Expressing Yersinia pestis F1 and V Antigens Protects against Bubonic and Pneumonic Plague
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1059–1067, https://doi.org/10.4049/jimmunol.178.2.1059
Innate Immune Responses to Endosymbiotic Wolbachia Bacteria in Brugia malayi and Onchocerca volvulus Are Dependent on TLR2, TLR6, MyD88, and Mal, but Not TLR4, TRIF, or TRAM
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1068–1076, https://doi.org/10.4049/jimmunol.178.2.1068
Activation of the MAPK, ERK, following Leishmania amazonensis Infection of Macrophages
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1077–1085, https://doi.org/10.4049/jimmunol.178.2.1077
Opsonization of HIV with Complement Enhances Infection of Dendritic Cells and Viral Transfer to CD4 T Cells in a CR3 and DC-SIGN-Dependent Manner
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1086–1095, https://doi.org/10.4049/jimmunol.178.2.1086
The Mechanism Underlying Defective Fcγ Receptor-Mediated Phagocytosis by HIV-1-Infected Human Monocyte-Derived Macrophages
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1096–1104, https://doi.org/10.4049/jimmunol.178.2.1096
Vasoactive Intestinal Peptide Balances Pro- and Anti-Inflammatory Cytokines in the Pseudomonas aeruginosa-Infected Cornea and Protects against Corneal Perforation
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1105–1114, https://doi.org/10.4049/jimmunol.178.2.1105
Inflammation
PDE4 Inhibition Prevents Preterm Delivery Induced by an Intrauterine Inflammation
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1115–1121, https://doi.org/10.4049/jimmunol.178.2.1115
Identification of Genes Selectively Regulated by IFNs in Endothelial Cells
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1122–1135, https://doi.org/10.4049/jimmunol.178.2.1122
CD99 Is a Key Mediator of the Transendothelial Migration of Neutrophils
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1136–1143, https://doi.org/10.4049/jimmunol.178.2.1136
Lipopolysaccharide-Induced Up-Regulation of Triggering Receptor Expressed on Myeloid Cells-1 Expression on Macrophages Is Regulated by Endogenous Prostaglandin E2
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1144–1150, https://doi.org/10.4049/jimmunol.178.2.1144
IL-8 and IDO Expression by Human Gingival Fibroblasts via TLRs
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1151–1157, https://doi.org/10.4049/jimmunol.178.2.1151
Human C-Reactive Protein Protects Mice from Streptococcus pneumoniae Infection without Binding to Pneumococcal C-Polysaccharide
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1158–1163, https://doi.org/10.4049/jimmunol.178.2.1158
MyD88-Dependent and MyD88-Independent Pathways in Synergy, Priming, and Tolerance between TLR Agonists
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1164–1171, https://doi.org/10.4049/jimmunol.178.2.1164
IFN-γ Alters the Response of Borrelia burgdorferi-Activated Endothelium to Favor Chronic Inflammation
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1172–1179, https://doi.org/10.4049/jimmunol.178.2.1172
Clinical Immunology
The Postnatal Maturation of the Immunoglobulin Heavy Chain IgG Repertoire in Human Preterm Neonates Is Slower than in Term Neonates
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1180–1188, https://doi.org/10.4049/jimmunol.178.2.1180
Functional Analysis of Birch Pollen Allergen Bet v 1-Specific Regulatory T Cells
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1189–1198, https://doi.org/10.4049/jimmunol.178.2.1189
Monocyte-Astrocyte Networks Regulate Matrix Metalloproteinase Gene Expression and Secretion in Central Nervous System Tuberculosis In Vitro and In Vivo
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1199–1207, https://doi.org/10.4049/jimmunol.178.2.1199
A Defect of Regulatory T Cells in Patients with Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy
The Journal of Immunology, Volume 178, Issue 2, January 2007, Pages 1208–1215, https://doi.org/10.4049/jimmunol.178.2.1208
