On the cover: Lipin-1 deficient bone marrow-derived Macrophages accumulate neutral lipids when stimulated with IL-4, a pro-resolving and lipid catabolism-inducing stimulus. Neutral lipids were stained with Nile Red, and cell nuclei were stained with DAPI. Bamgbose, T.T., R. M. Schilke, O. O. Igiehon, E. H. Nkadi, M. Binwal, C. David, S. Bharrhan, B. Schwarz, E. Bohrnsen, C. M. Bosio, R. S. Scott, A. Yurdagul, Jr, B. N. Finck, M. D. Woolard. 2025. Lipin-1 restrains macrophage lipid synthesis to promote inflammation resolution. J. Immunol. 214: 85–103

On the cover: Clonal analysis of monoclonal antibodies elicited by wild-type SARS-CoV-2 infection, mRNA and inactivated vaccines. Each dot represents an antibody, antibodies with connecting line belong to one clonotype, and the clonotypes shared between the inactivated vaccine group and other groups are framed by black dashed lines. Colors indicate different groups. Wang, M., C. Liu, Q. Fan, Y. Sun, S. Tang, H. Guo, B. Zhou, H. Wang, X. Ge, Z. Zhang, B. Ju. 2025. Rapid clonal expansion and somatic hypermutation contribute to the fate of SARS-CoV-2 broadly neutralizing antibodies. J. Immunol. 214: 278–289

On the cover: The distribution of Lr_Rel1 in kidney was measured by tissue immunofluorescence. Cai, Y., X. Du, A. Liu, M. Lv, F. Sun, P. Su. 2025. Transcription factor Rel regulates the transcription of effector genes involved in immune response by cooperating with IBs in lamprey (Lethenteron reissneri). J. Immunol. 214: 472–488

On the cover: Light microscopy image of antibody dependent cellular phagocytosis of rituximab opsonized primary chronic lymphocytic leukemia cells (green) mediated by human bone marrow monocyte-derived macrophages (gray). Original magnification x10. Smith, H. L., R. B. Foxall, P. J. Duriez, E. L. Teal, A. D. Hoppe, J. M. Kanczler, J. C. Gray, S. A. Beers. 2025. Comparison of Human Macrophages Derived from Peripheral Blood and Bone Marrow. J. Immunol. 214: 714–725