Volume 214, Issue 4
April 2025
Cover image
Cover image
On the cover: Light microscopy image of antibody dependent cellular phagocytosis of rituximab opsonized primary chronic lymphocytic leukemia cells (green) mediated by human bone marrow monocyte-derived macrophages (gray). Original magnification x10. Smith, H. L., R. B. Foxall, P. J. Duriez, E. L. Teal, A. D. Hoppe, J. M. Kanczler, J. C. Gray, S. A. Beers. 2025. Comparison of Human Macrophages Derived from Peripheral Blood and Bone Marrow. J. Immunol. 214: 714–725
ISSN 0022-1767
EISSN 1550-6606
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Volume 214, Issue 4, April 2025
Cutting Edge
The transcription factor RORα is required for the development of type 1 innate lymphoid cells in adult bone marrow
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 575–581, https://doi.org/10.1093/jimmun/vkaf001
Allergy and Other Hypersensitivities
Depletion of eosinophils during sensitization but not challenge phase in mice blocks the development of food allergy early in life
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 582–594, https://doi.org/10.1093/jimmun/vkae044
The Editors have selected this article as a highlight of the issue.
Antigen Recognition and Responses
HLA-E/peptide complexes differentially interact with NKG2A/CD94 and T cell receptors
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 595–605, https://doi.org/10.1093/jimmun/vkae068
Autoimmunity
Discovery of a new anti-γc antibody in clinical development for the treatment of autoimmune diseases
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 606–623, https://doi.org/10.1093/jimmun/vkae020
High-salt diet drives depression-like behavior in mice by inducing IL-17A production
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 624–635, https://doi.org/10.1093/jimmun/vkaf019
The Editors have selected this article as a highlight of the issue.
Clinical and Human Immunology
Cellular immune changes during severe antisense oligonucleotide-associated thrombocytopenia in a nonhuman primate model
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 636–650, https://doi.org/10.1093/jimmun/vkae055
Immune Regulation
Regulation of IL-17A–mediated hypersensitivity by extracellular vesicles and lipid nanoparticles carrying miR-451a
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 651–665, https://doi.org/10.1093/jimmun/vkae049
IL-7Rα signaling in regulatory T cells of adipose tissue is essential for systemic glucose homeostasis
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 666–679, https://doi.org/10.1093/jimmun/vkae064
High fat diet feeding impairs neutrophil phagocytosis, bacterial killing, and neutrophil-induced hematopoietic regeneration
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 680–693, https://doi.org/10.1093/jimmun/vkaf024
The Editors have selected this article as a highlight of the issue.
Immune System Development
IL-2Rα is dispensable for murine B cell development and humoral response
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 694–702, https://doi.org/10.1093/jimmun/vkae045
The Editors have selected this article as a highlight of the issue.
Infectious Disease and Host Response
CD209d/e are required for macrophage-mediated phagocytosis and activation during methicillin-resistant Staphylococcus aureus pulmonary host defense
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 703–713, https://doi.org/10.1093/jimmun/vkae061
Innate Immunity and Inflammation
Comparison of human macrophages derived from peripheral blood and bone marrow
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 714–725, https://doi.org/10.1093/jimmun/vkae032
Zebrafish (Danio rerio) TDP43 negatively regulates PKZ-IRF3–mediated IFN I response
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 726–746, https://doi.org/10.1093/jimmun/vkae035
Molecular and Structural Immunology
Peptide selectivity of killer cell immunoglobulin-like receptors differs with allotypic variation in HLA class I
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 747–761, https://doi.org/10.1093/jimmun/vkaf003
Exploring the genetic mechanisms driving KIR diversification
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 762–779, https://doi.org/10.1093/jimmun/vkae047
The Editors have selected this article as a highlight of the issue.
Mucosal Immunology
Gut IgA-antibody secreting cells segregate into four Blimp1+ subsets based on differential expression of IgA and Ki-67 and are retained following prolonged αCD20 B cell depletion in mice
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 780–794, https://doi.org/10.1093/jimmun/vkae046
Exacerbated endoplasmic reticulum stress transmitted by endometrial stromal cells alters the conditioning of tolerogenic dendritic cells affecting trophoblast migration
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 795–807, https://doi.org/10.1093/jimmun/vkae065
Combination therapy blocking TNF superfamily members 14 and 15 reverses pulmonary fibrosis
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 808–817, https://doi.org/10.1093/jimmun/vkaf002
The Editors have selected this article as a highlight of the issue.
Transplantation
DHODH inhibition alters T cell metabolism limiting acute graft-versus-host disease while retaining graft-versus-leukemia response
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 818–827, https://doi.org/10.1093/jimmun/vkaf023
The Editors have selected this article as a highlight of the issue.
Novel Immunological Methods
In vivo antibody labeling route and fluorophore dictate labeling efficiency, sensitivity, and longevity
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 828–838, https://doi.org/10.1093/jimmun/vkae051
Development and validation of a high throughput multiplex immunofluorescence assay to detect all human immunoglobulin isotypes and subclasses in human fluids
The Journal of Immunology, Volume 214, Issue 4, April 2025, Pages 839–849, https://doi.org/10.1093/jimmun/vkae048
