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Li-En Hsieh, John Sidney, David L Boyle, Gary S Firestein, Alessandro Sette, Alessandra Franco, IgG epitopes processed and presented by IgG+ B cells induce suppression by human thymic-derived regulatory T cells, The Journal of Immunology, Volume 206, Issue 1_Supplement, May 2021, Page 93.14, https://doi.org/10.4049/jimmunol.206.Supp.93.14
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Abstract
We described a human regulatory T cell (Treg) population activated by IgG+ B cells presenting peptides of the heavy constant region (Fc) via processing of the surface IgG underlying a model for B cell-Treg cooperation in the human immune regulation. Functionally, Treg inhibited the polarization of naive T cells toward a pro-inflammatory phenotype in both a cognate and a non-cognate fashion. Their fine specificities were similar in healthy donors and patients with rheumatoid arthritis (RA), a systemic autoimmune disease. Four immunodominant Fc peptides bound multiple HLA class II alleles and were recognized by most subjects in the two cohorts. The presentation of Fc peptides that stimulate Treg through the processing of IgG by dendritic cells occurred in myeloid dendritic cells cDC1 and cDC2. Different routes of antigen processing of the IgG impacted Treg expansion in RA patients.