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Abstract

Disclosure: A.E. Butler: None. A.S. Moin: None. T. Sathyapalan: None. S.L. Atkin: None.

Objective: Several risk factors in polycystic ovary syndrome (PCOS) are associated with increased risk for Alzheimer’s disease (AD). We hypothesized that circulatory levels of amyloid-related proteins would be elevated in PCOS but that these would potentially be mitigated by elevated levels of proteins associated with protection from AD. Methods: Somascan proteomic analysis of amyloid-related proteins was undertaken in a well validated PCOS database of 143 women with PCOS and 97 control women. Results: Amyloid-precursor protein (APP) (p<0.05), amyloid P-component (APCS) (p<0.001), apolipoprotein E (apoE) (p<0.01) and apoE3 (p<0.05) were elevated in PCOS, whilst alpha-synuclein (SNCA) (p<0.05) was reduced in PCOS, all features associated with increased AD risk. Correlation analyses of the AD-related proteins with protective heat shock proteins (HSPs) showed that SNCA positively correlated with HSP90 (p<0.01) and with HSP60 (p<0.0001). Correlations with markers of inflammation showed APCS positively correlated with interleukin-6 (IL6) (p<0.05) whilst ApoE and ApoE3 correlated positively with tumor necrosis factor-alpha (TNF-alpha) (p<0.05). Conclusion: The AD-associated protein pattern found in PCOS, with basal elevated APP and reduced SNCA, parallels what has been reported in patients type 2 diabetes. This dysregulated AD-related protein expression in PCOS is likely exacerbated by obesity and insulin resistance-related inflammation and may be modulated by protective HSP mechanisms.

Reference: Moin ASM, Al-Qaissi A, Sathyapalan T, Atkin SL, Butler AE. Hypoglycaemia in type 2 diabetes exacerbates amyloid-related proteins associated with dementia. Diabetes Obes Metab. 2021 Feb;23(2):338-349. doi: 10.1111/dom.14220. Epub 2020 Oct 25. PMID: 33026133.

Presentation Date: Saturday, June 17, 2023

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© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact [email protected]
Issue Section:
REPRODUCTIVE ENDOCRINOLOGY
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