Volume 106, Issue 5
May 2021
Cover image
Cover image
Light micrograph showing the full thickness of the adrenal gland. Credit: Michael Ross / Science Source
ISSN 0021-972X
EISSN 1945-7197
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Volume 106, Issue 5, May 2021
Mini-Reviews
SGLT2 Inhibitor–Induced Low-Grade Ketonemia Ameliorates Retinal Hypoxia in Diabetic Retinopathy—A Novel Hypothesis
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1235–1244, https://doi.org/10.1210/clinem/dgab050
Menopausal Hormone Therapy and Cardiovascular Disease: The Role of Formulation, Dose, and Route of Delivery
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1245–1254, https://doi.org/10.1210/clinem/dgab042
Clinical Research Articles
Association of Metformin with Susceptibility to COVID-19 in People with Type 2 Diabetes
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1255–1268, https://doi.org/10.1210/clinem/dgab067
Effect of Dapagliflozin on Urine Metabolome in Patients with Type 2 Diabetes
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1269–1283, https://doi.org/10.1210/clinem/dgab086
Cardiovascular Disease in Patients With Primary and Secondary Adrenal Insufficiency and the Role of Comorbidities
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1284–1293, https://doi.org/10.1210/clinem/dgab063
Improvement in A1c Levels in Early Adulthood in the T1D Exchange: Impact of Racial, Socioeconomic, and Clinical Factors
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1294–1302, https://doi.org/10.1210/clinem/dgab077
Vertebral Fracture Assessment in Postmenopausal Women With Postsurgical Hypoparathyroidism
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1303–1311, https://doi.org/10.1210/clinem/dgab076
Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1312–1324, https://doi.org/10.1210/clinem/dgab072
Statins Decrease the Risk of Orbitopathy in Newly Diagnosed Patients with Graves Disease
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1325–1332, https://doi.org/10.1210/clinem/dgab070
Identification and Clinical Associations of 3 Forms of Circulating T-cadherin in Human Serum
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1333–1344, https://doi.org/10.1210/clinem/dgab066
Efficacy and Safety of Dulaglutide in Older Patients: A post hoc Analysis of the REWIND trial
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1345–1351, https://doi.org/10.1210/clinem/dgab065
Total and Central Adiposity Are Associated With Age at Gonadarche and Incidence of Precocious Gonadarche in Boys
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1352–1361, https://doi.org/10.1210/clinem/dgab064
In Men With Obesity, T2DM Is Associated With Poor Trabecular Microarchitecture and Bone Strength and Low Bone Turnover
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1362–1376, https://doi.org/10.1210/clinem/dgab061
Effects of Vitamin D3 Supplementation on Body Composition in the VITamin D and OmegA-3 TriaL (VITAL)
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1377–1388, https://doi.org/10.1210/clinem/dgaa981
The Age-Dependent Changes of the Human Adrenal Cortical Zones Are Not Congruent
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1389–1397, https://doi.org/10.1210/clinem/dgab007
Impaired Suppression of Glucagon in Obese Subjects Parallels Decline in Insulin Sensitivity and Beta-Cell Function
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1398–1409, https://doi.org/10.1210/clinem/dgab019
Organoid Cultures Derived From Patients With Papillary Thyroid Cancer
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1410–1426, https://doi.org/10.1210/clinem/dgab020
Maternal Oxidative Stress Biomarkers in Pregnancy and Child Growth from Birth to Age 6
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1427–1436, https://doi.org/10.1210/clinem/dgab018
Nicotinamide Riboside Enhances In Vitro Beta-adrenergic Brown Adipose Tissue Activity in Humans
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1437–1447, https://doi.org/10.1210/clinem/dgaa960
18F-FDG-PET/CT Evaluation of Indeterminate Adrenal Masses in Noncancer Patients
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1448–1459, https://doi.org/10.1210/clinem/dgab005
A Pathophysiology of Type 2 Diabetes Unrelated to Metabolic Syndrome
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1460–1471, https://doi.org/10.1210/clinem/dgab057
Robust Neutralizing Antibodies to SARS-CoV-2 Develop and Persist in Subjects with Diabetes and COVID-19 Pneumonia
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1472–1481, https://doi.org/10.1210/clinem/dgab055
Genotype-Phenotype Correlation in Fibrous Dysplasia/McCune-Albright Syndrome
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1482–1490, https://doi.org/10.1210/clinem/dgab053
Long-term Effect of Aromatase Inhibition in Aromatase Excess Syndrome
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1491–1500, https://doi.org/10.1210/clinem/dgab054
Mifepristone Improves Adipose Tissue Insulin Sensitivity in Insulin Resistant Individuals
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1501–1515, https://doi.org/10.1210/clinem/dgab046
Characterization and Proteomic Analysis of Endometrial Stromal Cell–Derived Small Extracellular Vesicles
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1516–1529, https://doi.org/10.1210/clinem/dgab045
Approach to the Patient
Approach to the Virilizing Girl at Puberty
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages 1530–1539, https://doi.org/10.1210/clinem/dgaa948
Online Only Articles
Mini-Reviews
Metastatic Pheochromocytomas and Abdominal Paragangliomas
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e1937–e1952, https://doi.org/10.1210/clinem/dgaa982
Pitfalls in Performing and Interpreting Inferior Petrosal Sinus Sampling: Personal Experience and Literature Review
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e1953–e1967, https://doi.org/10.1210/clinem/dgab012
Clinical Research Articles
The Role of Metabolic Syndrome and its Components in Incident Fracture: A 15-Year Follow-Up Among the Iranian Population
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e1968–e1983, https://doi.org/10.1210/clinem/dgab023
Impact of a Gluten-Free Diet on Quality of Life and Health Perception in Patients With Type 1 Diabetes and Asymptomatic Celiac Disease
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e1984–e1992, https://doi.org/10.1210/clinem/dgaa977
Ascending Growth is Associated with Offspring Adiposity in Pregnancies Complicated with Obesity or Gestational Diabetes
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e1993–e2004, https://doi.org/10.1210/clinem/dgaa979
Dyslipidemia, Insulin Resistance, Ectopic Lipid Accumulation, and Vascular Function in Resistance to Thyroid Hormone β
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2005–e2014, https://doi.org/10.1210/clinem/dgab002
Cardiometabolic Profile of Different Body Composition Phenotypes in Children
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2015–e2024, https://doi.org/10.1210/clinem/dgab003
Postconvalescent SARS-CoV-2 IgG and Neutralizing Antibodies are Elevated in Individuals with Poor Metabolic Health
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2025–e2034, https://doi.org/10.1210/clinem/dgab004
Acute and Life-threatening Complications in Cushing Syndrome: Prevalence, Predictors, and Mortality
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2035–e2046, https://doi.org/10.1210/clinem/dgab058
Lactation Induction in a Transgender Woman Wanting to Breastfeed: Case Report
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2047–e2052, https://doi.org/10.1210/clinem/dgaa976
Prevalence and Features of Impaired Glucose Tolerance in Young Underweight Japanese Women
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2053–e2062, https://doi.org/10.1210/clinem/dgab052
Modified-Release Hydrocortisone in Congenital Adrenal Hyperplasia
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2063–e2077, https://doi.org/10.1210/clinem/dgab051
Dietary Pattern Trajectories from Youth to Adulthood and Adult Risk of Impaired Fasting Glucose: A 31-year Cohort Study
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2078–e2086, https://doi.org/10.1210/clinem/dgab044
Adrenal Venous Sampling in Young Patients with Primary Aldosteronism. Extravagance or Irreplaceable?
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2087–e2095, https://doi.org/10.1210/clinem/dgab047
Daytime Napping Duration Is Positively Associated With Risk of Hyperuricemia in a Chinese Population
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2096–e2105, https://doi.org/10.1210/clinem/dgab043
Association of Diabetes Subgroups With Race/Ethnicity, Risk Factor Burden and Complications: The MASALA and MESA Studies
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2106–e2115, https://doi.org/10.1210/clinem/dgaa962
Effect of a Multifactorial Intervention on Fracture in Patients With Type 2 Diabetes: Subanalysis of the J-DOIT3 Study
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2116–e2128, https://doi.org/10.1210/clinem/dgab013
Relationship of Preoperative Thyroid Dysfunction to Clinical Outcomes in Pediatric Cardiac Surgery
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2129–e2136, https://doi.org/10.1210/clinem/dgab040
Serum Follistatin Is Increased in Thyroid Cancer and Is Associated With Adverse Tumor Characteristics in Humans
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2137–e2150, https://doi.org/10.1210/clinem/dgab041
Changes in Ghrelin and Glucagon following a Low Glycemic Load Diet in Women with PCOS
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2151–e2161, https://doi.org/10.1210/clinem/dgab028
Potassium Concentration in Initial Fluid Therapy and In-Hospital Mortality of Patients with Diabetic Ketoacidosis
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2162–e2175, https://doi.org/10.1210/clinem/dgab029
Genetic Profiling of Orbital Fibroblasts from Patients with Graves’ Orbitopathy
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2176–e2190, https://doi.org/10.1210/clinem/dgab035
Epigenome-Wide Association Study of Thyroid Function Traits Identifies Novel Associations of fT3 With KLF9 and DOT1L
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2191–e2202, https://doi.org/10.1210/clinem/dgaa975
Glucose Metabolism After Pancreatectomy: Opposite Extremes Between Pancreaticoduodenectomy and Distal Pancreatectomy
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2203–e2214, https://doi.org/10.1210/clinem/dgab036
Impaired Immune Function in Patients With Chronic Postsurgical Hypoparathyroidism: Results of the EMPATHY Study
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2215–e2227, https://doi.org/10.1210/clinem/dgab038
Adipose Insulin Resistance and Decreased Adiponectin Are Correlated With Metabolic Abnormalities in Nonobese Men
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2228–e2238, https://doi.org/10.1210/clinem/dgab037
Systematic Quantification of Neurotrophic Adipokines RBP4, PEDF, and Clusterin in Human Cerebrospinal Fluid and Serum
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2239–e2250, https://doi.org/10.1210/clinem/dgaa983
Incidence and Clinical Presentation of Pheochromocytoma and Sympathetic Paraganglioma: A Population-based Study
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2251–e2261, https://doi.org/10.1210/clinem/dgaa965
Plasma Cell-Free DNA to Differentiate Malignant from Benign Thyroid Nodules
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2262–e2270, https://doi.org/10.1210/clinem/dgab030
Investigation of Mechanical, Material, and Compositional Determinants of Human Trabecular Bone Quality in Type 2 Diabetes
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2271–e2289, https://doi.org/10.1210/clinem/dgab027
Exocrine Pancreatic Function Modulates Plasma Metabolites Through Changes in Gut Microbiota Composition
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2290–e2298, https://doi.org/10.1210/clinem/dgaa961
Paraneoplastic Secretion of Multiple Phosphatonins From a Deep Fibrous Histiocytoma Causing Oncogenic Osteomalacia
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2299–e2308, https://doi.org/10.1210/clinem/dgaa964
Association Between Obstructive Sleep Apnea and Metabolic Abnormalities in Patients With Hypertrophic Cardiomyopathy
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2309–e2321, https://doi.org/10.1210/clinem/dgab015
Generation of β Cells from iPSC of a MODY8 Patient with a Novel Mutation in the Carboxyl Ester Lipase (CEL) Gene
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2322–e2333, https://doi.org/10.1210/clinem/dgaa986
A Set of Markers Related to Viral Infection Has a Sex-sensitive Prognostic Value in Papillary Thyroid Carcinoma
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2334–e2346, https://doi.org/10.1210/clinem/dgaa990
Dapagliflozin Added to Verinurad Plus Febuxostat Further Reduces Serum Uric Acid in Hyperuricemia: The QUARTZ Study
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2347–e2356, https://doi.org/10.1210/clinem/dgaa748
Commentaries
From the Tip to the Iceberg Below—Evolving Our Molecular Understanding of Thyroid Nodules
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2357–e2358, https://doi.org/10.1210/clinem/dgab087
Correction of the Gene Defect in Cystic Fibrosis: Is It Too Late for Bone?
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2359–e2361, https://doi.org/10.1210/clinem/dgab074
Diabetes Remission After Gastric Bypass: To Be or Not to Be Dependent on Weight Loss
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2362–e2364, https://doi.org/10.1210/clinem/dgab008
New Data to Challenge Gender-affirming Hormone Therapy Prescribing Practice
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2365–e2366, https://doi.org/10.1210/clinem/dgab006
The Use of IGF-I to Monitor Long-Acting Growth Hormone Therapy—Timing is an Art…
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2367–e2369, https://doi.org/10.1210/clinem/dgab016
The Intriguing Intersection of Type 2 Diabetes, Obesity-Related Insulin Resistance, and Osteoarthritis
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2370–e2372, https://doi.org/10.1210/clinem/dgab009
Does Early Identification of Central Congenital Hypothyroidism Result in Improved Outcomes?
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2373–e2375, https://doi.org/10.1210/clinem/dgab059
Letters to the Editor
Letter to the Editor from Watanabe et al: “Long-term Glycemic Variability and Vascular Complications in Type 2 Diabetes: Post Hoc Analysis of the FIELD Study”
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2376–e2377, https://doi.org/10.1210/clinem/dgab082
Letter to the Editor from Chenyun Miao, et al: “Effect of Diet on Insulin Resistance in Polycystic Ovary Syndrome”
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Pages e2378–e2379, https://doi.org/10.1210/clinem/dgab021
Corrigendum
Corrigendum to: “Generation of ß Cells From iPSC of a MODY8 Patient With a Novel Mutation in the Carboxyl Ester Lipase (CEL) Gene”
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 5, May 2021, Page e2380, https://doi.org/10.1210/clinem/dgab048
