-
Views
-
Cite
Cite
Kenji Obayashi, Keigo Saeki, Norio Kurumatani, Association Between Urinary 6-Sulfatoxymelatonin Excretion and Arterial Stiffness in the General Elderly Population: The HEIJO-KYO Cohort, The Journal of Clinical Endocrinology & Metabolism, Volume 99, Issue 9, 1 September 2014, Pages 3233–3239, https://doi.org/10.1210/jc.2014-1262
Close - Share Icon Share
Melatonin may have a preventive effect on atherosclerosis by regulating sleep quality and circadian biological rhythmicity. However, whether endogenous melatonin is associated with arterial stiffness, a marker reflecting atherosclerosis, is unclear.
The objective of the study was to determine the association between endogenous melatonin and arterial stiffness.
A total of 641 community-based elderly individuals were enrolled in this cross-sectional study (mean age 71.4 y).
We measured overnight urinary 6-sulfatoxymelatonin excretion (UME) and cardioankle vascular index (CAVI) as indices of melatonin secretion and arterial stiffness, respectively.
The median UME was 6.8 μg (interquartile range 4.1–10.5) and the mean value of CAVI was 9.1 ± 1.1. High CAVI (ie, ≥ 9.0) was observed in 334 participants (52.1%). Univariate logistic regression models revealed marginal to significant associations between high CAVI and age, gender, body mass index, hypertension, diabetes, estimated glomerular filtration rate, log-transformed UME, bedtime, duration in bed, daytime physical activity, and log-transformed nighttime physical activity. In the multivariate logistic regression model, simultaneously adjusted for the former independent variables, higher log-transformed UME was significantly associated with a lower odds ratio (OR) for high CAVI (adjusted OR 0.708; 95% confidence interval 0.536–0.935; P = .015). This inverse association between log-transformed UME and high CAVI indicated that an increase in log-transformed UME by 1 SD was associated with an 18.1% (95% confidence interval 1.4–31.9) decrease in high CAVI prevalence.
UME is significantly and inversely associated with arterial stiffness in the general elderly population. The association was independent of several major causes of atherosclerosis.
