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Denis Chemla, Pierre Attal, Luigi Maione, Anne-Sophie Veyer, Ghassan Mroue, Dany Baud, Sylvie Salenave, Peter Kamenicky, Serge Bobin, Philippe Chanson, Impact of Successful Treatment of Acromegaly on Overnight Heart Rate Variability and Sleep Apnea, The Journal of Clinical Endocrinology & Metabolism, Volume 99, Issue 8, 1 August 2014, Pages 2925–2931, https://doi.org/10.1210/jc.2013-4288
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Successful treatment of acromegaly improves disease-related cardiovascular mortality and morbidity, but its effects on autonomic modulation of the heart rate are unknown.
We documented treatment-induced changes in time-domain heart rate variability, taking into account the confounding effects of obstructive sleep apnea.
Sixteen consecutive patients (12 males, aged 43 ± 12 y) with newly diagnosed acromegaly underwent overnight (12:00–7:00 am) cardiac Holter recordings coupled with polysomnography. Data were obtained before and 10 ± 6 months after successful treatment of acromegaly.
IGF-1 levels fell from 807 ± 333 to 207 ± 69 μg/L and normalized in all patients. Seven patients (44%) had obstructive sleep apnea (apnea-hypopnea index 33 ± 21/h) at baseline. Treatment had no significant effect on polysomnographic indices. After treatment, increases were noted in the normal-to-normal heart period (NN), SD-NN, the percentage of NN differing from the previous NN by greater than 50 msec, and the root mean square of successive differences in NN (each P < .05). These heart rate variability results were not influenced by the type of treatment, and there was no relationship between changes in NN and changes in the apnea-hypopnea index (P = .58).
Early after successful treatment of acromegaly, we observed increased parasympathetic modulation/decreased sympathetic modulation of the nighttime heart rate, an effect that seems unrelated to changes in sleep apnea status. Treatments aimed at normalizing IGF-1 may improve cardiovascular homeostasis through improved cardiac autonomic nervous system modulation.