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Kan Nakamura, Mariko Ogata, Takao Ando, Toshiro Usa, Atsushi Kawakami, Paroxysmal Thyroid Swelling. A Forgotten Clinical Finding of Pheochromocytoma, The Journal of Clinical Endocrinology & Metabolism, Volume 96, Issue 12, 1 December 2011, Pages 3601–3602, https://doi.org/10.1210/jc.2011-1718
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A 29-yr-old woman was admitted to our hospital because of visible paroxysmal thyroid swelling (PTS) (Fig. 1) that developed 1 yr before. She had additional symptoms including palpitations, shortness of breath, and headaches that occurred every few days. Because she was found to have a left adrenal tumor, pheochromocytoma was suspected. Plasma catecholamine levels were unremarkable when she was asymptomatic. During symptomatic spells, she was hypertensive (180/100 mm Hg) and tachycardic (100 bpm) with high plasma epinephrine (417 pg/ml; <100 pg/ml) and norepinephrine (2665 pg/ml; 100 to 450 pg/ml). An ultrasound showed a transient (<15 to 60 min) thickening of the thyroid (Fig. 2). We also found that multiple intrathyroidal hypoechoic areas were reproducibly seen only during the spells, and some hypoechoic areas showed blood flow but others did not, suggesting edema, in the Doppler study (data not shown). The thyroid function tests (TSH, free T3, and free T4) taken before, during, and the day after the spell were unremarkable. The left adrenal tumor showed a positive 123I-metaiodobenzylguanidine accumulation, confirming pheochromocytoma. The patient underwent left adrenalectomy, and the histological finding was consistent with pheochromocytoma. Her symptom of PTS disappeared thereafter.
