Abstract

Concentrations of the α, β, and γsubunits of enolase in surgically resected tumors and serum obtained from patients with various endocrine tumors were measured by a sensitive enzyme immunoassay system. Tissue concentrations of the γsubunit were significantly elevated in patients with neuroendocrine tumors concurrent with high concentrations of the γsubunit in their serum, which fell to normal in 90% of those who underwent tumor resection. Immunohistochemical analysis revealed that considerable amounts of the γsubunit were contained specifically in these tumors. These results indicate that the γsubunit of enolase is a useful marker for diagnosing and monitoring patients with neuroendocrine tumors. (J Clin Endocrinol Metab63: 94,1986)

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