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Celso Gomez-Sanchez, David C. Kern, Norman M. Kaplan, A RADIOIMMUNOASSAY FOR PLASMA ALDOSTERONE BY IMMUNOLOGIC PURIFICATION, The Journal of Clinical Endocrinology & Metabolism, Volume 36, Issue 4, 1 April 1973, Pages 795–798, https://doi.org/10.1210/jcem-36-4-795
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A method for measuring aldosterone concentration has been improved by extracting the steroid from plasma with an antibody prior to radioimmunoassay. Precision, sensitivity and specificity were comparable in our laboratory to a method using paper chormatography and to published data for other methods. Duplicate specimens assayed with both methods gave a correlation of r = 0.91 (p < 0.005). This method eliminates chromatography and enables one technician to process 80–120 specimens each week.