Abstract

The acute effect of sodium fluoride on calcium metabolism and 45calcium kinetics in bone has been studied in 7 patients with osteoporosis and 1 patient with Paget's disease. Fluoride produced no significant change in calcium retention during 3 weeks of treatment. Nitrogen balance improved in 7 patients during treatment. Kinetic studies with 45calcium revealed that fluoride reduces the total exchangeable calcium significantly, without a significant reduction in bone formation or resorption rates.

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