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IRA L. SHANNON, JOHN R. PRIGMORE, ROBERT A. BROOKS, RALPH P. FELLER, THE 17-HYDROXYCORTICOSTEROIDS OF PAROTID FLUID, SERUM AND URINE FOLLOWING INTRAMUSCULAR ADMINISTRATION OF REPOSITORY CORTICOTROPIN, The Journal of Clinical Endocrinology & Metabolism, Volume 19, Issue 11, 1 November 1959, Pages 1477–1480, https://doi.org/10.1210/jcem-19-11-1477
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Abstract
In healthy young adult males, the intramuscular injection of 40 i.u. of corticotropin produced the expected elevations in the levels of serum and urinary 17-hydroxycorticosteroids (17-OHCS). The level of 17-OHCS in parotid-gland fluid closely paralleled that in the serum. These data strengthen the premise that the level of free 17-OHCS in parotid-gland fluid may well be utilized in evaluating adrenocortical status. The use of this method permits continuous sampling of a completely nonstressful nature and, even in extremely close quarters where blood sampling is impossible, the subject can easily obtain specimens of his own parotid fluid.