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STUART LINDSAY, MORRIS E. DAILEY, MALIGNANT LYMPHOMA OF THE THYROID GLAND AND ITS RELATION TO HASHIMOTO DISEASE: A CLINICAL AND PATHOLOGIC STUDY OF 8 PATIENTS, The Journal of Clinical Endocrinology & Metabolism, Volume 15, Issue 11, 1 November 1955, Pages 1332–1353, https://doi.org/10.1210/jcem-15-11-1332
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Abstract
MALIGNANT lymphoma (lymphosarcoma) is an uncommon, primaryneoplasm of the thyroid gland. Unlike most epithelial thyroid neoplasms, malignant lymphoma is usually characterized by a rapidly fatalcourse. The majority of the recorded cases of malignant lymphoma of the thyroid gland, including lymphosarcoma and reticulosarcoma, have been reviewed and tabulated by Dinsmore et al. (1), Kellett and Sutherland (2), and Brewer and Orr (3). Most of the patients reported were elderly women with rapidly growing goiters of recent origin, commonly associated with local symptoms of pressure. Usually the patients survived for only seven months to two years following surgical or radiation therapy.
The present study concerns 8 patients with malignant lymphoma originating in the thyroid gland. The glands of 7 of the 8 patients also displayed the characteristic lesions of Hashimoto disease. The relationship between these two thyroid processes appears significant.
The purposes of this report are 1) to describe the clinical manifestations of malignant lymphoma in these 8 patients and the course and results of surgical and radiation therapy, 2) to describe and illustrate the pathologic features of the disease, and 3) to discuss the relationship between malignant lymphoma and Hashimoto disease occurring together in the thyroid gland.