https://orcid.org/0000-0002-2762-6770
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Qingyan Chen, Dan Shan, Letter to the Editor From Chen and Shan: “Moderate-Intensity Combined Training Induces Lipidomic Changes in Individuals With Obesity and Type 2 Diabetes”, The Journal of Clinical Endocrinology & Metabolism, Volume 110, Issue 3, March 2025, Page e911, https://doi.org/10.1210/clinem/dgae684
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To the Editor,
We would like to discuss the findings presented in the recent study titled “Moderate-intensity combined training induces lipidomic changes in individuals with obesity and type 2 diabetes” by Duft et al (1). Their study offers valuable insights into the impact of combined training (CT) on lipid metabolism in individuals with obesity and type 2 diabetes (T2D). However, several points warrant further discussion, particularly concerning the study's design, statistical analysis, and the interpretation of results.
First, the study's methodological framework presents certain limitations that may affect the generalizability of the findings. Although the authors utilized a rigorous protocol for combined training, the lack of a control group with dietary intervention could be a critical oversight. The study acknowledges that participants maintained their usual dietary patterns, but it is well-documented that diet plays a significant role in lipid metabolism. Without controlling for dietary intake or including a dietary intervention group, it becomes challenging to attribute the observed lipidomic changes solely to the CT. For instance, evidence has shown that dietary modifications, particularly in fat composition, can independently alter lipid profiles in individuals with metabolic disorders (2). Therefore, the lack of dietary control in this study could introduce bias, leading to an overestimation of the effects of CT on lipid metabolism.
