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WILLIAM M. McCONAHEY, F. RAYMOND KEATING, RADIOIODINE STUDIES IN THYROIDITIS, The Journal of Clinical Endocrinology & Metabolism, Volume 11, Issue 10, 1 October 1951, Pages 1116–1122, https://doi.org/10.1210/jcem-11-10-1116
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Abstract
DESPITE considerable literature on the pathology of acute and chronic thyroiditis, comparatively little is known about the functional status of the thyroid in these conditions. Recently radioiodine tracer technic has provided a means of observing some aspects of thyroid function in thyroiditis. It is the purpose of this paper to present the results of radioiodine tracer studies performed on 40 patients, of whom 21 had acute diffuse thyroiditis, 13 had struma lymphomatosa and 6 had struma fibrosa.
Tracers consisting of 100 or 300 microcuries of I131 with 100 micrograms of sodium iodide added as carrier were administered by mouth to the subjects in the fasting state. After the ingestion of the I131, in vivo counts were taken over the thyroid at twenty-four or forty-eight hours as described by Luellen and associates (1), and urinary excretion of I131 was evaluated as described by Keating and associates (2). From the curve of urinary excretion, two rates were estimated: 1) the renal excretion rate, defined as the proportional rate at which inorganic radioiodide is being removed from the blood by the kidneys, and 2) the extrarenal disposal rate, defined as the proportional rate at which radioiodide is being removed from the blood by all tissues other than the kidneys. The values for these rates in our patients with thyroiditis are compared with the values in euthyroid persons reported elsewhere (Table 1).
