-
Views
-
Cite
Cite
Lewis M. Hurxthal, Howard N. Simpson, HYPERCHOLESTEROLEMIA, The Journal of Clinical Endocrinology & Metabolism, Volume 1, Issue 5, 1 May 1941, Pages 450–452, https://doi.org/10.1210/jcem-1-5-450
Close - Share Icon Share
Abstract
IT IS WELL KNOWN that hypercholesterolemia is an almost invariable finding in either spontaneous or postoperative myxedema. This has been con-firmed from numerous sources (1, 2). It may also be found in other disorders, and at times in apparently normal individuals. It is, therefore, not pathognomonic of thyroid deficiency. Likewise, no other single physical abnormality, symptom or other laboratory finding is in itself diagnostic of myxedema. Hyper-cholesterolemia is as consistent an abnormality as any found in this disorder, and therefore deserves its share of importance in the diagnostic survey.
Experience has demonstrated that it is safe to con’ elude that a level of 300 mg. of cholesterol per 100 cc. of blood is well above the average normal value, which is approximately 180 mg. per 100 cc. We have shown diagrammatically in figure 1 what we believe is a reasonable scale of normal values. With this in mind, we felt that valuable information might be ob-tained by studying all case records in which a blood cholesterol value of over 300 mg. was found. In a 7-year period from Jan. 1, 1932, to Dec. 31, 1938, 404 such individuals were seen at the Lahey Clinic.
