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MATTHEW M. STEINER, JOSEPH D. BOGGS, Absence of Pituitary Gland, Hypothyroidism, Hypoadrenalism and Hypogonadism in a 17-Year-Old Dwarf, The Journal of Clinical Endocrinology & Metabolism, Volume 25, Issue 12, 1 December 1965, Pages 1591–1598, https://doi.org/10.1210/jcem-25-12-1591
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Absence of the pituitary gland, hypothyroidism, hypoadrenalism and hypogonadism has been reported in a 17-yr-old male dwarf with myxedema, hypoglycemicconvulsions and marked genital underdevelopment. There was no pituitary gland within the fossa, and no ectopic cells were found in the tissue between the sella turcica and the posterior pharynx. Histologically, only a small nest of cells was found, which could not be recognized as pituitary cells. There was gross disorganization of the thyroid and no normal thyroid architecture or follicular structure. The adrenals were small and the architecture was distorted by diffuse interstitial fibrous tissue surrounding small islets of cortical cells. The testes were minute and only atrophic remnants of seminiferous tubules remained surrounded by diffuse dense fibrous tissue. The relationship between the endocrinopathy and the life history of the patient is discussed.