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CARL D. STROUSE, E. E. ROSENBAUM, ROBERT C. LEVY, SAMUEL SOSKIN, Intensive Carbohydrate Therapy in Diabetic Patients with Manifest or Suspected Liver Disease, The Journal of Clinical Endocrinology & Metabolism, Volume 1, Issue 10, 1 October 1941, Pages 831–835, https://doi.org/10.1210/jcem-1-10-831
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Abstract
THE IMPORTANT ROLE OF THE LIVER in carbohydrate metabolism, first demonstrated by Claude Bernard, has been reviewed recently by one of us (1). It is generally recognized that the glycogen stores of this organ have an important bearing upon its functional integrity and upon its resistance to damaging agents, and wide use has been made of high carbohydrate therapy in liver disease (2). Recent work has clearly shown that the liver is a major factor in the maintenance of the normal blood sugar level. Diabetes mellitus may be regarded as a disturbance in this homeostatic regulation because of a relative lack of insulin or a relative excess of the opposing endocrine factors. The endocrine balance controls the level at which the liver regulates the blood sugar. Under these circumstances it is readily understandable that liver disease which interferes with the responsiveness of this organ to endocrine influences alters carbohydrate tolerance in the non-diabetic organism and decreases the effectiveness of administered insulin in the diabetic patient (3).