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THOMAS H. McGAVACK, G. PAUL CHARLTON, SOLOMON KLOTZ, Effect of Desoxycorticosterone Acetate on Glucose Tolerance in Normal Individuals and in Patients with Addison’s Disease, The Journal of Clinical Endocrinology & Metabolism, Volume 1, Issue 10, 1 October 1941, Pages 824–830, https://doi.org/10.1210/jcem-1-10-824
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Abstract
DESOXYCORTICOSTERONE HAS BEEN RECOGNIZED as the most effective of the cortical adrenomimetic steroids so far used in the treatment of adrenalectomised animals and patients with Addison’s disease (1, 2). However, certain toxic manifestations and its apparently limited influence upon carbohydrate metabolism have tended to restrict its judicious application to human beings. It is the purport of the present study to show that large doses can be used for relatively long periods of time in the management of the disease without untoward effect, provided adherence to certain rules is observed. Moreover, data relative to variations in blood glucose levels under varying conditions are presented in detail to suggest the role that desoxycorticosterone may be capable of playing in intermediary carbohydrate metabolism.