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KATSUMI IWASE, AKIO NAGASAKA, KANEFUSA KATO, SUSUMU OHTANl, IKUKO NAGATSU, TAKAKO OHYAMA, AKIRA NAKAI, TOSHIHIRO AONO, HIFUMI NAKAGAWA, SHIGEHIRO SHINODA, MASANARI INAGAKI, TOKEI TEI, SHUICHI MIYAKAWA, KYOHEI KAWASE, KAORU MIURA, TARO NAKAMURA, TETSUO KANNO, AKIO KUWAYAMA, NAOKI KAGEYAMA, Enolase Subunits in Patients with Neuroendocrine Tumors, The Journal of Clinical Endocrinology & Metabolism, Volume 63, Issue 1, 1 July 1986, Pages 94–101, https://doi.org/10.1210/jcem-63-1-94
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Abstract
Concentrations of the α, β, and γsubunits of enolase in surgically resected tumors and serum obtained from patients with various endocrine tumors were measured by a sensitive enzyme immunoassay system. Tissue concentrations of the γsubunit were significantly elevated in patients with neuroendocrine tumors concurrent with high concentrations of the γsubunit in their serum, which fell to normal in 90% of those who underwent tumor resection. Immunohistochemical analysis revealed that considerable amounts of the γsubunit were contained specifically in these tumors. These results indicate that the γsubunit of enolase is a useful marker for diagnosing and monitoring patients with neuroendocrine tumors. (J Clin Endocrinol Metab63: 94,1986)