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Journal Article
ACCEPTED MANUSCRIPT
Zero-hour thresholds to risk stratify patients for acute myocardial infarction using a point-of-care high-sensitivity troponin assay
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Jaimi H Greenslade and others
European Heart Journal. Acute Cardiovascular Care, zuaf068, https://doi.org/10.1093/ehjacc/zuaf068
Published: 02 May 2025
... Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Background and Aims High-sensitivity cardiac troponin (hs-cTn) assays are crucial in assessing suspected myocardial infarction (MI). International recommendations recommend evaluating new assays to identify metrics...
Journal Article
ACCEPTED MANUSCRIPT
Loss of MRAP2 in MC4R neurons protect from obesity-associated autonomic and cardiovascular dysfunctions
Deng Fu Guo and others
Cardiovascular Research, cvaf067, https://doi.org/10.1093/cvr/cvaf067
Published: 17 April 2025
... of MRAP2 in MC4R neurons, with a particular focus on autonomic and cardiovascular functions. Methods and Results Selective deletion of MRAP2 in MC4R neurons causes obesity that was associated with hyperphagia and impairment in glucose homeostasis and insulin sensitivity. MC4R agonist Melatonan II (MTII...
Journal Article
Low-density lipoprotein cholesterol, C-reactive protein, and lipoprotein(a) universal one-time screening in primary prevention: the EPIC-Norfolk study
Jordan M Kraaijenhof and others
European Heart Journal, ehaf209, https://doi.org/10.1093/eurheartj/ehaf209
Published: 01 April 2025
...-sensitivity C-reactive protein (hsCRP), and lipoprotein(a) [Lp(a)] in primary prevention. This study addresses the validity and generalizability of this novel primary prevention strategy in a large prospective European cohort of initially healthy men and women. Methods Plasma levels of LDL cholesterol...
Journal Article
Clinical derivation and data simulated validation of rule-out and rule-in algorithms for the Siemens Atellica IM high-sensitivity cardiac troponin I assay
Ingar Ziad Restan and others
European Heart Journal. Acute Cardiovascular Care, Volume 14, Issue 3, March 2025, Pages 155–168, https://doi.org/10.1093/ehjacc/zuaf017
Published: 28 January 2025
...—for further information please contact journals.permissions@oup.com. Abstract Aims This prospective, two-centre study derived and validated predictive algorithms for the Siemens Atellica IM high-sensitivity cardiac troponin I (hs-cTnI) assay in the emergency department (ED). Methods and results...
Journal Article
End-of-life issues in the intensive therapy unit: 10 important points to remember
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Jean-Louis Vincent
European Heart Journal. Acute Cardiovascular Care, Volume 14, Issue 4, April 2025, Pages 245–249, https://doi.org/10.1093/ehjacc/zuaf011
Published: 21 January 2025
... and effective communication with the whole ITU team, including the patient and their family. In this article, we discuss 10 key considerations related to EOL care in the ITU, in an attempt to highlight some critical aspects of EOL decision-making for intensivists navigating this sensitive and multifaceted area...
Journal Article
Autonomic cardiac control independently predicts incident hypertension and systolic blood pressure in a multi-ethnic population: the HELIUS study
Thomas A Bouwmeester and others
European Journal of Preventive Cardiology, zwaf011, https://doi.org/10.1093/eurjpc/zwaf011
Published: 16 January 2025
..., systolic blood pressure. Corresponding author. Tel: +0031 205669111, Email: b.j.vandenborn@amsterdamumc.nl Lay Summary Cross-correlation baroreflex sensitivity (xBRS) and heart rate variability (HRV) are associated with cardiac autonomic function, and they predict blood pressure increases in a multi...
Journal Article
EDITOR'S CHOICE
Association of modifiable lifestyle risk factors with high-sensitivity troponin T and I concentrations and clinical outcomes
Benjamin Bay and others
European Journal of Preventive Cardiology, zwae374, https://doi.org/10.1093/eurjpc/zwae374
Published: 26 November 2024
...:https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Aims We aimed to investigate the association between the burden of modifiable lifestyle risk factors (modLRF) with high-sensitivity cardiac troponins T and I (hsTnT/I) and clinical outcomes in a contemporary cohort. Methods and results...
Journal Article
Single high-sensitivity troponin-I for ruling out acute coronary syndrome: a detection limit approach
Siobhan Hickling and others
European Heart Journal Open, Volume 4, Issue 6, November 2024, oeae094, https://doi.org/10.1093/ehjopen/oeae094
Published: 20 November 2024
...) are a leading cause of presentation to Emergency Departments (ED). However, the incidence of acute myocardial infarction (MI) in this population is low. 1 Current European guidelines for management of ACS recommend using serial (at presentation and 1 or 2 h later) high-sensitivity cardiac troponin...
Journal Article
Emergency department use of a high-sensitivity point-of-care troponin assay reduces length of stay: an implementation study preliminary report
John W Pickering and others
European Heart Journal. Acute Cardiovascular Care, Volume 13, Issue 12, December 2024, Pages 838–842, https://doi.org/10.1093/ehjacc/zuae114
Published: 15 October 2024
..., and reproduction in any medium, provided the original work is properly cited. Abstract Aims Point-of-care (POC) high-sensitivity troponin (hs-cTn) assays within a clinical pathway may safely reduce length of stay (LoS) for patients presenting to the emergency department (ED) with possible acute myocardial...
Journal Article
A computational study on the influence of antegrade accessory pathway location on the 12-lead electrocardiogram in Wolff–Parkinson–White syndrome
Karli Gillette and others
in
EP Europace
EP Europace, Volume 27, Issue 2, February 2025, euae223, https://doi.org/10.1093/europace/euae223
Published: 11 September 2024
... morphological patterns originating from diverse cardiac regions. We then applied variance-based sensitivity analysis relying on polynomial chaos expansion on the ECG database to mathematically quantify how variation in AP location and timing relates to morphological variation in the 12-lead ECG. We utilized our...
Journal Article
Diagnosis of acute myocardial infarction in patients with renal failure using high-sensitivity cardiac troponin T
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Jonathan D Knott and others
European Heart Journal. Acute Cardiovascular Care, Volume 13, Issue 7, July 2024, Pages 546–558, https://doi.org/10.1093/ehjacc/zuae079
Published: 02 July 2024
... disease. CI, confidence interval; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; hs-cTnT, high-sensitivity cardiac troponin T. Myocardial infarction High-sensitivity cardiac troponin T Chronic kidney disease Wayne and Kathryn Preisel Chair in Cardiovascular Disease Research See...
Journal Article
EDITOR'S CHOICE
Point-of-care high-sensitivity cardiac troponin in suspected acute myocardial infarction assessed at baseline and 2 h
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Louise Cullen and others
European Heart Journal, Volume 45, Issue 28, 21 July 2024, Pages 2508–2515, https://doi.org/10.1093/eurheartj/ehae343
Published: 06 June 2024
...-of-care (POC) high-sensitivity cardiac troponin I (hs-cTnI) assay may expedite emergency care. A 2-h POC hs-cTnI strategy for emergency patients with suspected AMI was derived and validated. Methods In two international, multi-centre, prospective, observational studies of adult emergency patients...
Journal Article
Combining anatomical and biochemical markers in the detection and risk stratification of coronary artery disease
Miriam Albus and others
European Heart Journal - Cardiovascular Imaging, Volume 25, Issue 9, September 2024, Pages 1197–1205, https://doi.org/10.1093/ehjci/jeae093
Published: 09 April 2024
... atherosclerosis with high-sensitivity cardiac troponin as a quantitative biochemical marker of myocardial injury provided incremental value in the detection of functionally relevant coronary artery disease (fCAD) and risk stratification. Methods and results Consecutive patients undergoing myocardial perfusion...
Journal Article
Association of inflammatory markers with incident heart failure or cancer in the HUNT3 and Health ABC population studies
Edoardo Bertero and others
European Journal of Preventive Cardiology, Volume 31, Issue 11, August 2024, Pages 1400–1407, https://doi.org/10.1093/eurjpc/zwae089
Published: 01 March 2024
... on the article page on our site—for further information please contact journals.permissions@oup.com. Abstract Aims To investigate the relationship between chronic low-grade inflammation, as measured by high-sensitivity C-reactive protein (hsCRP) levels, and incident heart failure (HF) or cancer. Methods...
Journal Article
A systematic review and meta-analysis of transthoracic echocardiogram vs. cardiac magnetic resonance imaging for the detection of left ventricular thrombus
YuZhi Phuah and others
European Heart Journal - Imaging Methods and Practice, Volume 1, Issue 2, September 2023, qyad041, https://doi.org/10.1093/ehjimp/qyad041
Published: 07 December 2023
... then reported along with sensitivity and specificity results. Additional data points, including the type of CMR imaging utilized as a reference, the time interval between TTE and CMR, and patient demographics such as age and male percent (%) were collected. Patient data on cardiovascular risk factors...
Journal Article
Agreement among high-sensitivity cardiac troponin assays and non-invasive testing, clinical outcomes, and quality-of-care outcomes based on the 2020 European Society of Cardiology Guidelines
Júlia Karády and others
European Heart Journal. Acute Cardiovascular Care, Volume 13, Issue 1, January 2024, Pages 15–23, https://doi.org/10.1093/ehjacc/zuad146
Published: 24 November 2023
...-sensitivity troponin assays 6 LOD LOQ Overall 99th %tile Sex-specific 99th %tile, female/male Roche Elecsys, TnT, ng/L 5 6 19 14/22 Abbott Architect, TnI, ng/L 1.7 2.3 28 17/35 Siemens Vista, TnI, ng/L 2 3 58.9 53.7/78.5 Beckmann Access, TnI, ng/L 1–2...
Journal Article
Absence of visible infarction on cardiac magnetic resonance imaging despite the established diagnosis of myocardial infarction by 4th Universal Definition of Myocardial Infarction
Janek Salatzki and others
European Heart Journal. Acute Cardiovascular Care, Volume 13, Issue 1, January 2024, Pages 24–35, https://doi.org/10.1093/ehjacc/zuad128
Published: 24 October 2023
...Janek Salatzki; Evangelos Giannitsis; Anastasia Hegenbarth; Matthias Mueller-Hennessen; Florian André; Norbert Frey; Moritz Biener Acute myocardial infarction Infarct mass High-sensitivity troponin T Late gadolinium enhancement In a recent study, 137 patients who had a confirmed diagnosis...
Journal Article
Exercise oscillatory ventilation: the past, present, and future
Gonçalo Cunha and others
European Journal of Preventive Cardiology, Volume 30, Issue Supplement_2, October 2023, Pages ii22–ii27, https://doi.org/10.1093/eurjpc/zwad205
Published: 11 October 2023
... in the setting of heart failure and other diagnoses. Heart Failure Exercise oscillatory ventilation Chemoreceptor sensitivity Circulatory delay Exercise oscillatory ventilation (EOV) pattern was first recognized in the cardiopulmonary exercise test (CPET) of patients with severe heart failure (HF...
Journal Article
GUIDELINES
2023 ESC Guidelines for the management of acute coronary syndromes: Developed by the task force on the management of acute coronary syndromes of the European Society of Cardiology (ESC)
Robert A Byrne and others
European Heart Journal. Acute Cardiovascular Care, Volume 13, Issue 1, January 2024, Pages 55–161, https://doi.org/10.1093/ehjacc/zuad107
Published: 22 September 2023
... cardiac care Acute coronary syndrome Antithrombotic therapy Fibrinolysis High-sensitivity troponin Invasive strategy MINOCA Myocardial infarction Non-ST-elevation myocardial infarction Patient-centred care Percutaneous coronary intervention Recommendations Reperfusion therapy...
Journal Article
GUIDELINES
2023 ESC Guidelines for the management of acute coronary syndromes: Developed by the task force on the management of acute coronary syndromes of the European Society of Cardiology (ESC)
Robert A Byrne and others
European Heart Journal, Volume 44, Issue 38, 7 October 2023, Pages 3720–3826, https://doi.org/10.1093/eurheartj/ehad191
Published: 25 August 2023
... Antithrombotic therapy Fibrinolysis High-sensitivity troponin Invasive strategy MINOCA Myocardial infarction Non-ST-elevation myocardial infarction Patient-centred care Percutaneous coronary intervention Recommendations Reperfusion therapy Revascularization Secondary prevention ST-segment elevation...