... inhibited liver X receptor alpha (LXRα), and interacted directly with transcription factor EB (TFEB) to suppress autophagy, resulting in lipid accumulation and inflammation in macrophages. Additionally, 2′-deoxycytidine concentration dependently decreased Dax1 levels, enhanced autophagy, reduced lipid...

...Celia Ruperez; Frank Madeo; Rafael de Cabo; Guido Kroemer; Mahmoud Abdellatif Cardiovascular disease Inflammation Autophagy Mitochondrial dysfunction Senescence SGLT2 GLP-1 Caloric restriction Medical University of Graz 10.13039/501100010109 BioTechMed-Graz 10.13039/501100019802...

... Autophagy Mitophagy NAD⁺ metabolism European Research Area Network on Cardiovascular Diseases 10.13039/501100020407 MINOTAUR consortium Austrian Science Fund 10.13039/501100002428 Medical University of Graz 10.13039/501100010109 BioTechMed-Graz 10.13039...

... in the aortas of MFS mice; MFS × CKO mice showed aggravated TAA, inflammation, extracellular matrix remodelling, and TGF-β pathway activation compared to MFS mice. Mechanistically, PIEZO1 knockout exacerbated the activation of the TGF-β signalling pathway by inhibiting the endocytosis and autophagy...

... sequencer. Detailed descriptions were given in the Supplementary material online . Our materials and methods, including a detailed table of the resources used in this study, are described in the Supplementary material online . We have demonstrated that YTHDF1 controls CF autophagy and fibrosis via...

... Autophagy Inflamm-ageing Swiss Heart Foundation 10.13039/501100004362 Foundation for Cardiovascular Research 10.13039/100007555 Swiss National Science Foundation 10.13039/501100001711 Foundation for Cardiovascular Research—Zurich Heart House Lindenhof Foundation...

...Mahmoud Abdellatif; Sophie T Schmid; Alexander Fuerlinger; Guido Kroemer Figure 2 Targetable mechanistic nodes of autophagy regulation. Autophagy checkpoints, which have a suppressing effect on autophagy, are highlighted in red, while autophagy-activating targets are shown in grey. ACBP, acyl-CoA...

... ^{, 63} with both empagliflozin and dapagliflozin enhancing autophagy in cardiometabolic disease models via the activation of nutrient-sensing pathways such as the mTOR, sirtuin1 (SIRT1), and hypoxia-inducible factor (HIS) pathway. ^64–66 19 10 2023 03 01 2024 05 02 2024...

... phosphatidylinositol signalling, facilitates autophagy, and acts as an mRNA stabilizer. HuR positively modulated PIP4K2A expression at the post-transcriptional level and consequently influenced the AKT/mTOR/ATG13 pathway to regulate autophagy and CAVD progression. Conclusion Our study provides new insights...

... and autophagy-related gene expression. (A–C) Immunocytochemical analysis of HCAECs with adenoviral-mediated overexpression of OSGIN 1 + 2 (scale bar 100 µm). β-Catenin (a marker of intercellular junctional stability), vinculin (focal adhesions) and phalloidin (Actin), Tubulin and VE-Cadherin...

... The senescence assay was read under a standard light microscope and the extent of the blue-stained area was evaluated by image analysis. Autophagy in murine heart sections and cardiomyocytes plated in chamber slides were detected by Autophagy Detection Kit (Abcam ab139484, Cambridge, UK), as previously...

... comparison test (H–O, Q–S). Figure 5 Inhibition of the ceramide de novo biosynthesis with myriocin restores CM autophagy and prevents HF in absence of Nogo-A. (A) WB analysis and quantification of (B) LC3B-II and (C) BECLIN-1 expression in CM from Nogo...

...Yasuhiro Maejima; Daniela Zablocki; Jihoon Nah; Junichi Sadoshima Figure 5 A schematic representation of autophagy-mediated regulation of YAP. The level of YAP is critically regulated by the autophagy machinery via various pathways (see text for details and definitions of abbreviations). Ac...

...Giampaolo Morciano; Simone Patergnani; Gaia Pedriali; Paolo Cimaglia; Elisa Mikus; Simone Calvi; Alberto Albertini; Carlotta Giorgi; Gianluca Campo; Roberto Ferrari; Paolo Pinton Autophagy is a physiological process needed for cell survival and for maintaining cellular functions. ⁷...

... trafficking and autophagy in Ugcg-deficient cardiomyocytes. We also showed that responsiveness to β-adrenergic stimulation was reduced in cardiomyocytes from hUgcg  ^–/– mice and that Ugcg knockdown suppressed the internalization and trafficking of β1-adrenergic receptors...

... Mühlfeld; Christoph Maack; Simon Sedej Graphical Abstract Cardiomyocytes Calcium Mitochondria Autophagy Beta-adrenergic signalling Austrian Science Fund (FWF) P27637-B28 I3301-MINOTAUR BioTechMed-Graz [Young Researcher Groups Medical University of Graz scholarship European...

... Autophagy Commentary on ‘A network of macrophages supports mitochondrial homeostasis in the heart’ by J.A. Nicolás-Ávila et al. 2020, Cell 183, 94–109.e23. Genetic and acquired mitochondria dysfunction has a profound impact on cardiac performance and contributes to cardiovascular ageing...

... under the terms of the Oxford University Press, Standard Journals Publication Model ( https://dbpia.nl.go.kr/journals/pages/open_access/funder_policies/chorus/standard_publication_model ) Autophagy Macrophage Mitochondria Metabolism Heart Commentary on ‘A network of macrophages supports...

... as reference. EF, ejection fraction; GRK4, G protein-coupled receptor kinase 4. * Adjusted for basic characteristics described in Table  1 , GRK 486 A:V and GRK4 486 V:V were compared with GRK4 486 A:A. Figure 4 G protein-coupled receptor kinase 4 decreases cardiomyocyte autophagy in post...

..., as this occurs upon starvation, mTORC1 is inhibited, leading to autophagy induction and cell survival ⁶¹ (further details will be addressed in the next section). CR also dampens mTORC1 activity, thereby reducing ageing in several animal models. ^{46 , 62} In support...