
Contents
Cite
Extract
Summary
Non-invasive images of the myocardium that reflect myocardial perfusion can be obtained either by using conventional nuclear medicine radiopharmaceuticals and cameras or by positron emission tomography (PET). Myocardial perfusion scintigraphy (MPS) with thallium-201 and/or technetium (Tc)-99m-labelled sestamibi and tetrofosmin, in combination with single photon emission computed tomography (SPECT), is a robust and well validated technique for the identification of myocardial ischaemia and infarction with high sensitivity and specificity. 99mTc-labelled myocardial perfusion agents have a high-count density which enables acquisition of electrocardiogram-gated images. Spatial and temporal changes in activity during the cardiac cycle reflect regional myocardial motion and thickening and this technique allows left ventricular volume, ejection fraction, and myocardial motion and thickening to be measured in addition to the information on perfusion. Since the main feature of an acute coronary syndrome is reduced myocardial perfusion, MPS can provide important diagnostic and prognostic information in the emergency department and allows patient stratification in the post-infarction phase. PET provides absolute measurement of myocardial blood flow and has enabled the demonstration of coronary microvascular dysfunction. This has highlighted the potential contribution of the microcirculation to myocardial ischaemia in patients with angiographically normal coronary arteries. Both SPECT and PET are invaluable tools for the identification of viable myocardium in patients with coronary artery disease and congestive heart failure. The constant technological developments of non-invasive cardiac imaging over the past years, including the advent of hybrid nuclear and computer tomography (CT) scanners now allow image fusion of CT coronary angiography and nuclear imaging which can be achieved by using hybrid scanners or software fusion of data sets obtained from stand-alone scanners. Although the potential of such comprehensive non-invasive coronary artery disease assessment appears great, the clinical impact of this tool remains to be established.
Sign in
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Purchase
Our books are available by subscription or purchase to libraries and institutions.
Purchasing informationMonth: | Total Views: |
---|---|
October 2022 | 4 |
February 2023 | 2 |
October 2023 | 2 |
December 2023 | 1 |
January 2024 | 1 |
June 2024 | 1 |
July 2024 | 2 |
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.