In rats maintained on a normal diet parathyroidectomy resulted in a hypercalciuric response which persisted for periods up to 4 weeks. In view of the marked hypocalcemia existing throughout the 4-week period, it is concluded that removal of the parathyroids results in a chronic increase in calcium clearance. Serum magnesium and urinary magnesium and inorganic phosphate data are also reported. Chronic parathyroidectomy resulted in the expected fall in urinary inorganic phosphate. Serum magnesium fell following parathyroidectomy; urinary magnesium levels were unaffected by the operation. (Endocrinology79: 77, 1966)

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