-
Views
-
Cite
Cite
JOHN R. CORTELYOU, AILEEN HIBNER-OWERKO, JOSEPH MULROY, BLOOD AND URINE CALCIUM CHANGES IN TOTALLY PARATHYROIDECTOMIZED RANA PIPIENS, Endocrinology, Volume 66, Issue 3, 1 March 1960, Pages 441–450, https://doi.org/10.1210/endo-66-3-441
- Share Icon Share
Abstract
The effects of parathyroidectomy in Rana pipiens are being investigated in our laboratories. The results of the work being reported demonstrate that the calcium concentration in whole blood and plasma gradually decrease 50 to 60% below the control values within 1 to 2 weeks. However, a hypocalcemia is not permanent as is evidenced by the fact that at the end of 29 weeks the whole blood calcium of the operated animals returned to 8.3 mg.% which approximates the lowest calcium values obtained from unoperated animals. Calcium concentrations in urine taken from the parathyroidectomized animals on different days are 13 to 78% above the control values. These results indicate that in parathyroidectomized frogs there is a loss of calcium through the urinary system which is concomitant with the decrease in plasma calcium. No death from tetany occurred in the operated animals even when their blood or plasma calcium was at its lowest levels.