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JAMES H. LEATHEM, INFLUENCE OF THIOUREA ON PLASMA PROTEINS AND ORGAN WEIGHTS IN THE RAT, Endocrinology, Volume 36, Issue 2, 1 February 1945, Pages 98–103, https://doi.org/10.1210/endo-36-2-98
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Abstract
HYPOPHYSECTOMY in the rat is followed by a rise in serum globulin concentration and a decrease in serum albumin whereas thyroi-dectomy is followed by a rise in serum globulin but the albumin concentration remains unchanged. (Levin and Leathern, 1942; Levin 1943). Administration of thyroxine to the hypophysectoroized rat prevents the rise in serum globulin without preventing the decrease in serum albumin thus indicating a relationship between thyroid function and serum globulin concentration (Levin and Leathern, 1942). Since it is well established that thiourea will induce hypertrophy of the thyroid and is thought to prevent the formation of thyroid hormone (MacKenzie and MacKenzie, 1943; Astwood, Sullivan, Bissell and Tyslowitz, 1943; Astwood, 1943; Keston, Goldsmith, Gordon and Charipper, 1944; Franklin, Lerner and Chaikoff, 1944), it appeared of interest to determine whether feeding thiourea would result in blood protein changes similar to those induced by thyroid-ectomy.