Abstract

THE FOLLOWING case record is reported in detail because of the apparent association of an increased urinary excretion of sodium pregnanediol glucuronide (metabolic product of progesterone) with the symptomatology of the patient and because of the subjective relief afforded the patient by intensive endocrine therapy which depressed the metabolism of progesterone and decreased the urinary titers of the pregnanediol complex.

CASE REPORT A white married woman, aged 27 years, para O'O'O, was seen first in the Endo crine Division of Duke University Hospital on March 4, 1938 because of a cyclic dermatosis occurring during the progestational stage of the menstrual cycle, poly hypermenorrhea, dysmenorrhea and menstrual headache of approximately one year's duration.

No significant familial data existed. There had been no abnormalities of somatic development or of sexual maturation. Menarche occurred at 14 years of age.

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