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Walter Timme, A NEW PLURIGLANDULAR COMPENSATORY SYNDROME, Endocrinology, Volume 2, Issue 3, 1 July 1918, Pages 209–240, https://doi.org/10.1210/endo-2-3-209
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Abstract
For the past six years there have come to my notice in my service at the Neurological Institute, New York City, as well as in private work, a fairly large number of eases in early adolescence whose chief complaint was great muscular fatigability. Usually combined with this outstanding symptom was headache referred to the frontal region and midway between the temples. Included in the history was frequently a statement of recent or concurrent rapid growth in height as well as of the extremities. Frequent repetition of these complaints in various individuals led me to go deeply into their antecedent history, their family history, and to follow the cases as carefully as possible during their course. Their clinical examinations also showed many characteristics in common, as did their laboratory and X-ray findings. Finally, one case, observed for six years, went through various stages to recovery at the age of thirty-two years. From his early history we recognized symptoms that are presented by cases observed from time to time in the beginning stages of this syndrome, notably the fatigability, the headaches, and the skeletal growth. “Cross Sections” at various stages of his further progress also resembled clinical pictures in different patients that had heretofore been somewhat puzzling to analyze.
