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L.F. Fanjul, C.M. Ruiz de Galarreta, Aaron J.W. Hsueh, PROGESTTN AUGMENTATION OF GONADOTROPIN-STIMULATED PROGESTERONE PRODUCTION BY CULTURED RAT GRANULOSA CELLS, Endocrinology, Volume 112, Issue 1, 1 January 1983, Pages 405–407, https://doi.org/10.1210/endo-112-1-405
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Ovarian progesterone production is stimulated by FSH and LH. Concomitant treatment with a synthetic progestin, R5020, (10-6 M) increases the FSH-stimulated production of progesterone and 20α-hydroxypregn-4-en-3-one (20α-OH-P) in cultured rat granulosa cells. Likewise, R5020 augments the LH-stimulated progestin production in FSH-primed cells. Furthermore, the FSH stimulation of pregnenolone biosynthesis is enhanced by 10-6 M of progesterone or R5020. These in vitro findings suggest that progestins may exert an autoregulatory positive feedback action to enhance gonadotropin-stimulated production of progesterone and 20α-OH-P.