Placebo Effects Through the Lens of Translational Research
Placebo Effects Through the Lens of Translational Research
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Abstract
This book sheds light on the translation of current mechanistic research on placebo effects to develop comprehensive and adequate strategies for better symptom management and treatment. This book identifies three core aspects to bridge state-of-the-art concepts with day-to-day clinical practice. First, lessons from mechanistic placebo research indicate a neurobiological basis underlying placebo effects. Second, placebo research can improve the design of clinical trials to advance drug development. Third, placebo effects can be exploited in daily clinical practice to optimize patient-clinician communication and relationships and clinical outcomes. Together, these three core aspects provide a new perspective with which to appraise the implications of Placebo Research for healthcare systems, clinicians, patients, and caregivers. New patient-centered approaches, mental health, and pain-related issues are discussed while describing technologically advanced and novel research applications that will shift current clinical practice to improve treatment outcomes.
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Front Matter
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1 Placebo effects: An introduction
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1.1
From placebo research to healing
Wayne B. Jonas
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1.2
Expectations: What do we know and where do we need to go?
Sigrid Juhl Lunde and others
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1.3
New translational opportunities for placebo research
Ben Alter and others
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1.4
Cultural influences on placebo and nocebo effects
Rachel L. Cundiff-O’Sullivan and others
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1.1
From placebo research to healing
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2 Placebos and their predictability
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2.1
Predictability of placebo responses and their clinical implications
Paulo Branco and others
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2.2
Molecular mechanisms of placebo responses: From genes to pathways
Hailey Yetman and others
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2.3
Dynamic regulation of genes in placebo responsiveness in alcohol use disorder and co-occurring pain
Chamindi Seneviratne and others
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2.4
Placebos meet proteomics: Predicting and monitoring placebo effects by plasma proteins
Karin Meissner and others
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2.1
Predictability of placebo responses and their clinical implications
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3 Placebos and nocebos across conditions
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3.1
The role of sleep disturbance in endogenous pain modulation through opioidergic, placebo, and positive affective mechanisms
Patrick H. Finan and others
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3.2
Placebo effects in cough
Ronald Eccles
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3.3
Learned immune responses: How associations affect immunity
Stefanie Hölsken and others
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3.4
Placebo effects in sports performance and exercise outcomes
Jacob B. Lindheimer and others
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3.5
Nocebos in migraine: Implications for clinical research and practice
Dimos D. Mitsikostas
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3.6
Placebos, nocebos, and COVID-19: Society, science, and health care during the pandemic
Leonard Calabrese
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3.1
The role of sleep disturbance in endogenous pain modulation through opioidergic, placebo, and positive affective mechanisms
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4 Placebos and nocebos in mental illnesses
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4.1
A model of placebo responses in antidepressant clinical trials
Sigal Zilcha-Mano andBret R. Rutherford
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4.2
Placebo and nocebo effects in depression: Implications for treatment and clinical trial designs
Winfried Rief and others
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4.3
Expectations and placebo effects in the context of cognitive training
Jocelyn Parong and others
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4.4
Why psychotherapy is an open-label placebo and open-label placebos are psychotherapy
Jens Gaab
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4.1
A model of placebo responses in antidepressant clinical trials
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5 Putting placebos into practice
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5.1
Placebo responses and effects: Processes, potential, and ethical considerations in clinical care
Nikola Boris Kohls and others
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5.2
Putting placebos into practice: From mechanisms to making patients better
Damien G. Finniss and others
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5.3
Management of contextual factors to enhance placebo and minimize nocebo effects in clinical practice
Marco Testa and others
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5.4
Placebo effects and research quality: What is good evidence?
Wayne B. Jonas and others
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5.1
Placebo responses and effects: Processes, potential, and ethical considerations in clinical care
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6 Current and future directions: Digital health and health equity
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6.1
Using the person-based approach to implement placebo research into primary care
Felicity L. Bishop and others
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6.2
Sharing online clinical notes with patients: Implications for placebo and nocebo effects and racial health equity
Charlotte Blease
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6.3
The rise of digital health and digital medicine: How digital technologies will change or affect placebo and nocebo effects
Ellenor Brown and others
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6.4
A glimpse of the multiple applications of virtual reality: Analgesia, embodiment and rehabilitation, interactive education, and communication
Yang Wang and others
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6.1
Using the person-based approach to implement placebo research into primary care
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End Matter
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