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Definition Definition
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Neurobiology (Scientific Fundamentals) Neurobiology (Scientific Fundamentals)
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Direct Toxicity Direct Toxicity
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Indirect Toxicity Indirect Toxicity
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Clinical Presentation Clinical Presentation
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Abnormal Growth Abnormal Growth
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Dysmorphism Dysmorphism
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Central Nervous System Abnormalities Central Nervous System Abnormalities
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Laboratory Tests Laboratory Tests
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Differential Diagnosis Differential Diagnosis
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Management and Treatment Management and Treatment
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General Management General Management
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Pharmacologic Treatment Pharmacologic Treatment
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Behavioral and Special Education Interventions Behavioral and Special Education Interventions
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Medical Conditions Medical Conditions
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Future Directions Future Directions
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References References
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Additional Resources Additional Resources
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179 Neurobiology of Fetal Alcohol Spectrum Disorders
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Published:August 2016
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Abstract
Prenatal exposure to ethanol can result in a wide range of clinical presentations that are grouped under the term “Fetal Alcohol Spectrum Disorders” (FASD). The direct cellular teratogenic effects of ethanol on fetal neurodevelopment include damage to cell survival, proliferation, and migration mechanisms. Dysregulation of neurotransmission and alteration of genetic transcription have also been implicated in the neurotoxic effects of prenatal ethanol exposure. These deleterious events lead to brain volume reduction, corpus callosum dysgenesis, cerebellar, and other neuroanatomical anomalies that have been observed in individuals with FASD. Beyond direct ethanol-induced insults, the impact that ethanol has on maternal nutrition, metabolism, hormonal regulation, and placental physiology also adversely effects fetal development. The complex interactions between numerous neurobiological and psychosocial mechanisms that hinder optimal fetal neurodevelopment are reflected by the heterogeneous clinical presentation of FASD, including impaired growth, dysmorphic facial features, and cognitive and behavioral disorders.
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