
Contents
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Overview Overview
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General General
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Clinical Heterogeneity and Differential Symptoms Across Stages Clinical Heterogeneity and Differential Symptoms Across Stages
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Symptoms to Target Symptoms to Target
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Commonalities in Symptoms and Disease Targets Across the Degenerative Dementias Commonalities in Symptoms and Disease Targets Across the Degenerative Dementias
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An Empiric Strategy for Symptomatic Treatment of Alzheimer’s Disease An Empiric Strategy for Symptomatic Treatment of Alzheimer’s Disease
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Current Pharmacologic Treatment Current Pharmacologic Treatment
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Cognitive Therapies Cognitive Therapies
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Overview Overview
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Cholinesterase Inhibitors Cholinesterase Inhibitors
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N-methyl-D-aspartate (NMDA) Antagonists N-methyl-D-aspartate (NMDA) Antagonists
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Behavioral and Psychiatric Symptom Management Behavioral and Psychiatric Symptom Management
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Overview Overview
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Antidepressants Antidepressants
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Anxiolytics Anxiolytics
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Antipsychotics Antipsychotics
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Stimulants Stimulants
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Mood Stabilizers Mood Stabilizers
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Antihypertensives Antihypertensives
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Metabolic and Nutritional strategies Metabolic and Nutritional strategies
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Overview Overview
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Supplements Supplements
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Vitamin E Vitamin E
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Omega-3 Fatty Acids Omega-3 Fatty Acids
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B Vitamins and Folate B Vitamins and Folate
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Huperzine Huperzine
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Dietary Modification Dietary Modification
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Medium Chain Triglycerides Medium Chain Triglycerides
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Souvenaid® Souvenaid®
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Mediterranean Diet Mediterranean Diet
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Cholesterol Lowering Agents Cholesterol Lowering Agents
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Nonpharmacologic Strategies Nonpharmacologic Strategies
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Overview Overview
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Cognitive Training Cognitive Training
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Exercise Exercise
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Behavioral Management Behavioral Management
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Caregiver Training and Support Caregiver Training and Support
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Failed Strategies of Important Clinical Interest Failed Strategies of Important Clinical Interest
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Overview Overview
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Hormone Replacement Therapy Hormone Replacement Therapy
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Nonsteroidal Anti-inflammatory Drugs, Steroids, and Intravenous Immunoglobulin Nonsteroidal Anti-inflammatory Drugs, Steroids, and Intravenous Immunoglobulin
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Gingko Biloba Gingko Biloba
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Experimental Disease-Modifying Strategies Experimental Disease-Modifying Strategies
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Overview Overview
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Amyloid Amyloid
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Tau Tau
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Symptomatic Treatments Symptomatic Treatments
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Metabolic Modulators Metabolic Modulators
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Reseveratrol Reseveratrol
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Insulin Insulin
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The Right Agent at the Right Time: Future Directions in Clinical Trial Design and Disease Intervention The Right Agent at the Right Time: Future Directions in Clinical Trial Design and Disease Intervention
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Conclusions Conclusions
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References References
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17 Alzheimer’s Disease: Management and Treatment
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Published:August 2016
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Abstract
Advances in the current management and treatment of Alzheimer’s disease have grown directly from our increased understanding of the neurobiology underlying this disease. Currently available pharmacologic and nonpharmacologic treatment strategies remain focused on symptomatic management of disease rather than disease modification. Despite a wealth of evidence supporting the clinical benefits of existing therapies in the management of symptomatic progression, there is limited evidence that these available therapies modify disease progression over the course of dementia progression. More recent research discoveries in the areas of genetics, molecular and cell biology, and environmental risk factors have become the focal point for an explosive growth in experimental disease-modifying strategies designed to prevent, slow, or potentially halt the progression of Alzheimer’s disease.
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