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Definition Definition
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Introduction Introduction
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Epidemiology Epidemiology
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Neurobiology of Central Nervous System Infections Neurobiology of Central Nervous System Infections
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Pathogenesis Pathogenesis
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Neuropatholgy Neuropatholgy
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Clinical Presentation Clinical Presentation
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Laboratory Tests Laboratory Tests
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Lumbar Puncture Lumbar Puncture
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Tissue Identification Tissue Identification
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Culture Methods Culture Methods
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Serology Serology
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Molecular Diagnosis by Polymerase Chain Reaction Molecular Diagnosis by Polymerase Chain Reaction
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Neuroimaging Neuroimaging
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Diiferential Diagnosis Diiferential Diagnosis
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Management and Treatment Management and Treatment
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Prevention Prevention
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Conclusion Conclusion
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Future Directions Future Directions
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References References
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Additional Resources Additional Resources
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165 Amoebic Infections of the Central Nervous System
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Published:August 2016
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Abstract
Free-living amoebae are ubiquitous and can cause severe infections of the nervous system. The pathogenesis involves neuronal damage due to the activation of inflammatory cascade induced by the pathogenic amoebae, including both acute fulminant and chronic granulomatous inflammation. The diagnosis requires high clinical suspicion; eliciting history of contact with water or soil habitats of free-living amoebae is important. The chapter provides an overview of the different types of nervous system infections caused by the four genera of free-living amoebae, including their pathogenesis, rapid diagnostic tools, clinical features, and treatment strategies. Management includes timely, appropriate, and adequate antimicrobial therapy and supportive care.
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