Manual of Childhood Infections: The Blue Book (3 edn)
Annotate
Cite
Extract
see also Chapters 27, 44
Name and Nature of Organism
...
Epidemiology
...
Pathogenesis
The disease process in pertussis is multifactorial and dependent on several B. pertussis virulence factors. These factors, alone or in combination, enable the organism to:
...
The principal factors include those that have been included in the new acellular pertussis vaccines:
...
Other factors may also include:
...
Transmission
...
Clinical Features and Sequelae
There are typically three stages of pertussis disease.
Catarrhal
...
Spasmodic
...
Convalescent
...
Atypical Features
...
Major complications and deaths occur most commonly in infants <6 months of age. These include:
...
Minor complications include:
...
Diagnosis
Pertussis is largely diagnosed clinically. Confirmation of the diagnosis or corroborative evidence may be obtained from a history of contact with a case and/or laboratory investigations. Advances in diagnostic techniques such as PCR assays have improved laboratory diagnosis of pertussis in addition to the traditional culture and serology testing.
Sign in
Get help with access
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.