Manual of Childhood Infections: The Blue Book (3 edn)
Annotate
Cite
Extract
see also Chapters 6, 8, 15, 17, 20, 22, 23, 28, 29, 30, 51, 55, 110
Introduction
Conventional amphotericin B deoxycholate, fluconazole, and 5-fluorocytosine (5-FC) have until recently been the mainstay of antifungal therapy in invasive fungal infection (IFI). Lipid amphotericin preparations are less toxic than conventional preparations, and along with azole antifungal agents, increase the options for treating invasive fungal diseases. With the advent of novel azoles, such as voriconazole and posaconazole, along with echinocandin drugs such as caspofungin, treatment can be tailored to the fungus species isolated and its drug sensitivity, as well as the degree of risk from immunosuppression. However, there is a paucity of high-quality data evaluating the efficacy of antifungal drugs in children, and paediatric pharmacokinetic data for the older and the newer antifungal agents are limited, making research in this field a key priority. For all drug doses, see Appendix 5.
Fungal classification
Yeasts:
Sign in
Get help with access
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.