
Published online:
01 September 2012
Published in print:
01 May 2011
Online ISBN:
9780199965151
Print ISBN:
9780195339970
Contents
-
-
-
-
-
-
-
-
-
-
Neurotransmitters differ in their distribution, ubiquity, and function Neurotransmitters differ in their distribution, ubiquity, and function
-
Neurotransmitters share a restricted number of mechanisms for synthesis, packaging, and termination of effect Neurotransmitters share a restricted number of mechanisms for synthesis, packaging, and termination of effect
-
Neurotransmitter synthesis occurs locally except in the case of peptides Neurotransmitter synthesis occurs locally except in the case of peptides
-
Neurotransmitters are packaged into vesicles, except in the case of gases Neurotransmitters are packaged into vesicles, except in the case of gases
-
The effect of neurotransmitters is terminated by uptake, degradation, and diffusion The effect of neurotransmitters is terminated by uptake, degradation, and diffusion
-
Low-molecular-weight neurotransmitters are the workhorses of the nervous system Low-molecular-weight neurotransmitters are the workhorses of the nervous system
-
Acetylcholine is synthesized in the neuronal terminal and rapidly degraded in the synaptic cleft Acetylcholine is synthesized in the neuronal terminal and rapidly degraded in the synaptic cleft
-
Monoamines share a common packaging mechanism Monoamines share a common packaging mechanism
-
Monoamines act in a hormone-like fashion, rather than at classical synapses Monoamines act in a hormone-like fashion, rather than at classical synapses
-
Monoamines are critical to mood and affect Monoamines are critical to mood and affect
-
Catecholamines share synthetic and packaging steps but have distinct uptake mechanisms Catecholamines share synthetic and packaging steps but have distinct uptake mechanisms
-
Serotonin is formed from tryptophan by tryptophan hydroxylase Serotonin is formed from tryptophan by tryptophan hydroxylase
-
Each monoamine can be transported by a number of molecules Each monoamine can be transported by a number of molecules
-
Neurons and glia cooperate to synthesize glutamate Neurons and glia cooperate to synthesize glutamate
-
Glutamate is the substrate for GABA synthesis Glutamate is the substrate for GABA synthesis
-
Peptides are derived from large precursors Peptides are derived from large precursors
-
Nitric oxide serves as a retrograde signal Nitric oxide serves as a retrograde signal
-
A variety of molecules can have neurotransmitter-like effects on neurons A variety of molecules can have neurotransmitter-like effects on neurons
-
Additional reading Additional reading
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Chapter
7 Synthesis, Packaging, and Termination of Neurotransmitters
Get access
Pages
103–126
-
Published:May 2011
Cite
Mason, Peggy, 'Synthesis, Packaging, and Termination of Neurotransmitters', Medical Neurobiology, 1 edn (2011; online edn, Oxford Academic, 1 Sept. 2012), https://doi.org/10.1093/med/9780195339970.003.0007, accessed 7 May 2025.
Abstract
The synthesis, packaging, and termination of action for low-molecular-weight, peptide, and gaseous neurotransmitters are detailed.
Keywords:
low-molecular-weightneurotransmitters, peptideneurotransmitters, gas neurotransmitters, acetylcholine, monoamines, catecholamines, dopamine, norepinephrine, serotonin, nitric oxide -neurotransmittersynthesisvesicular transporters, uptake, anticholinesterase, volume transmission, phenylketonuria, monomine oxidase, monomine oxidase inhibitors, tricyclic antidepressants, selective serotonin reuptake inhibitors, neurotransmitter-specific transporters, cocaine, amphetamine, glutamate excitotoxicity, glutamate-glutamine cycle, stiff-person syndrome, ketogenic diet, retrograde synaptic signal
Collection:
Oxford Medicine Online
Disclaimer
Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct.
Readers must therefore always …
More
Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct.
Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets
provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or
legal liability for any errors in the text or for the misuse or misapplication of material in this work. Except where otherwise stated, drug dosages
and recommendations are for the non-pregnant adult who is not breastfeeding.
© Oxford University Press
You do not currently have access to this chapter.
Sign in
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Purchase
Our books are available by subscription or purchase to libraries and institutions.
Purchasing informationMetrics
View Metrics
Metrics
Total Views
6
6
Pageviews
0
PDF Downloads
Since 10/1/2022
Month: | Total Views: |
---|---|
October 2022 | 1 |
February 2023 | 1 |
June 2024 | 1 |
August 2024 | 3 |
Citations
Altmetrics
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.