
Contents
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Pathophysiology and Clinical Findings Pathophysiology and Clinical Findings
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Osteoporosis and Osteomalacia Osteoporosis and Osteomalacia
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Other Corticosteroid Effects Other Corticosteroid Effects
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Bisphosphonates Bisphosphonates
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Myopathy and Tendinopathy Myopathy and Tendinopathy
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Fluorosis Fluorosis
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Imaging Strategy Imaging Strategy
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Imaging Findings Imaging Findings
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Osteoporosis or Osteomalacia Osteoporosis or Osteomalacia
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Osteonecrosis and Bone Infarct Osteonecrosis and Bone Infarct
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Atypical Femur Fractures Atypical Femur Fractures
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Osteonecrosis of the Mandible Osteonecrosis of the Mandible
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Voriconazole Voriconazole
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Myositis Myositis
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Treatment Options Treatment Options
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Medication-Induced Osteoporosis Medication-Induced Osteoporosis
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Osteonecrosis Osteonecrosis
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Atypical Femoral Fractures Atypical Femoral Fractures
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Osteonecrosis of the Jaw Osteonecrosis of the Jaw
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Voriconazole Voriconazole
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Recommended Reading Recommended Reading
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References References
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117 Medication-Induced Musculoskeletal Changes
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Published:April 2019
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Abstract
Chapter 117 discusses common medication-induced changes of the musculoskeletal system. The effect of corticosteroids on the musculoskeletal system, including osteoporosis and osteonecrosis, is discussed. Corticosteroids decrease osteoblastic activity, stimulate bone resorption, and decrease intestinal absorption of calcium. Complications of bisphosphonate therapy such as atypical femoral fractures and osteonecrosis of the jaw are reviewed. Myopathies and tendon pathologies are briefly discussed, as well as bony changes potentially seen with long-term voriconazole treatment. For osteoporosis, DXA scan is the gold standard, whereas radiography is usually the first imaging modality performed in patients on voriconazole therapy who present with pain.
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