Volume 122, Issue 2, August 2011

SOCIETY OF TOXICOLOGY 50TH ANNIVERSARY INVITED CONTRIBUTION

Toxicology and Epidemiology: Improving the Science with a Framework for Combining Toxicological and Epidemiological Evidence to Establish Causal Inference

Hans-Olov Adami and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 223–234, https://doi.org/10.1093/toxsci/kfr113

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BIOMARKERS OF TOXICITY

Biological Qualification of Biomarkers of Chemical-Induced Renal Toxicity in Two Strains of Male Rat

Ernie Harpur and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 235–252, https://doi.org/10.1093/toxsci/kfr112

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Blood Gene Expression Profiling Detects Silica Exposure and Toxicity

Rajendran Sellamuthu and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 253–264, https://doi.org/10.1093/toxsci/kfr125

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BIOTRANSFORMATION AND TOXICOKINETICS

Accumulation and Debromination of Decabromodiphenyl Ether (BDE-209) in Juvenile Fathead Minnows (Pimephales promelas) Induces Thyroid Disruption and Liver Alterations

Pamela D. Noyes and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 265–274, https://doi.org/10.1093/toxsci/kfr105

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Modeling of the Internal Kinetics of Benzo(a)pyrene and 3-Hydroxybenzo(a)pyrene Biomarker from Rat Data

Roberto Heredia-Ortiz and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 275–287, https://doi.org/10.1093/toxsci/kfr135

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Inhibition of Renal NQO1 Activity by Dicoumarol Suppresses Nitroreduction of Aristolochic Acid I and Attenuates its Nephrotoxicity

Min Chen and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 288–296, https://doi.org/10.1093/toxsci/kfr138

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Physiologically Based Pharmacokinetic Modeling of Fetal and Neonatal Manganese Exposure in Humans: Describing Manganese Homeostasis during Development

Miyoung Yoon and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 297–316, https://doi.org/10.1093/toxsci/kfr141

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CARCINOGENICITY

Highlighted Article

Perturbation of Mitosis through Inhibition of Histone Acetyltransferases: The Key to Ochratoxin A Toxicity and Carcinogenicity?

Kristin Czakai and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 317–329, https://doi.org/10.1093/toxsci/kfr110

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Transcriptional Profile of Diuron-Induced Toxicity on the Urinary Bladder of Male Wistar Rats to Inform Mode of Action

Shadia M. Ihlaseh and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 330–338, https://doi.org/10.1093/toxsci/kfr108

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CARCINOGENECITY

Delay of Gap Filling during Nucleotide Excision Repair by Base Excision Repair: The Concept of Competition Exemplified by the Effect of Propolis

Mei-Kuang Chen and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 339–348, https://doi.org/10.1093/toxsci/kfr107

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CARCINOGENICITY

The Interplay of the Aryl Hydrocarbon Receptor and β-Catenin Alters Both AhR-Dependent Transcription and Wnt/β-Catenin Signaling in Liver Progenitors

Jiřina Procházková and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 349–360, https://doi.org/10.1093/toxsci/kfr129

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cAMP-Dependent Cytosolic Mislocalization of p27^kip-Cyclin D1 During Quinol-Thioether–Induced Tuberous Sclerosis Renal Cell Carcinoma

Jennifer D. Cohen and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 361–371, https://doi.org/10.1093/toxsci/kfr118

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ENDOCRINE TOXICOLOGY

Characterization of Novel Ligands of ERα, Erβ, and PPARγ: The Case of Halogenated Bisphenol A and Their Conjugated Metabolites

Anne Riu and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 372–382, https://doi.org/10.1093/toxsci/kfr132

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ENVIRONMENTAL TOXICOLOGY

Joint Effects of Heterogeneous Estrogenic Chemicals in the E-Screen—Exploring the Applicability of Concentration Addition

Elisabete Silva and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 383–394, https://doi.org/10.1093/toxsci/kfr103

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Transmembrane Transport of Microcystin to Danio rerio Zygotes: Insights into the Developmental Toxicity of Environmental Contaminants

Chao Song and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 395–405, https://doi.org/10.1093/toxsci/kfr131

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GENETIC TOXICOLOGY

Site-Specific In Vivo Mutagenicity in the Kidney of gpt Delta Rats Given a Carcinogenic Dose of Ochratoxin A

Daisuke Hibi and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 406–414, https://doi.org/10.1093/toxsci/kfr139

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Assessment of an Association between an Aryl Hydrocarbon Receptor Gene (AHR) Polymorphism and Risk of Male Infertility

Aihua Gu and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 415–421, https://doi.org/10.1093/toxsci/kfr137

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IN VITRO METHODS AND ALTERNATIVES TO ANIMALS

The Incorporation of Lysine into the Peroxidase Peptide Reactivity Assay for Skin Sensitization Assessments

John A. Troutman and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 422–436, https://doi.org/10.1093/toxsci/kfr101

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Time-Response Evaluation by Transcriptomics of Methylmercury Effects on Neural Differentiation of Murine Embryonic Stem Cells

Peter T. Theunissen and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 437–447, https://doi.org/10.1093/toxsci/kfr134

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MOLECULAR TOXICOLOGY

Epigenetic Mechanisms of Mouse Interstrain Variability in Genotoxicity of the Environmental Toxicant 1,3-Butadiene

Igor Koturbash and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 448–456, https://doi.org/10.1093/toxsci/kfr133

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Involvement of MicroRNAs in Dioxin-Induced Liver Damage in the Mouse

Wataru Yoshioka and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 457–465, https://doi.org/10.1093/toxsci/kfr130

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Genetic Architecture of Susceptibility to PCB126-Induced Developmental Cardiotoxicity in Zebrafish

Eric R. Waits and Daniel W. Nebert

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 466–475, https://doi.org/10.1093/toxsci/kfr136

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Organotins Are Potent Activators of PPARγ and Adipocyte Differentiation in Bone Marrow Multipotent Mesenchymal Stromal Cells

Susan C. Yanik and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 476–488, https://doi.org/10.1093/toxsci/kfr140

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NANOTOXICOLOGY

Predictive Toxicology of Cobalt Nanoparticles and Ions: Comparative In Vitro Study of Different Cellular Models Using Methods of Knowledge Discovery from Data

Limor Horev-Azaria and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 489–501, https://doi.org/10.1093/toxsci/kfr124

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NEUROTOXICOLOGY

1,3-Dinitrobenzene–Induced Metabolic Impairment through Selective Inactivation of the Pyruvate Dehydrogenase Complex

James A. Miller and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 502–511, https://doi.org/10.1093/toxsci/kfr102

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Mechanism of Pyrethroid Pesticide–Induced Apoptosis: Role of Calpain and the ER Stress Pathway

Muhammad M. Hossain and Jason R. Richardson

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 512–525, https://doi.org/10.1093/toxsci/kfr111

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Nigrostriatal Proteomics of Cypermethrin-Induced Dopaminergic Neurodegeneration: Microglial Activation-Dependent and -Independent Regulations

Anand Kumar Singh and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 526–538, https://doi.org/10.1093/toxsci/kfr115

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Arsenite Exposure Downregulates EAAT1/GLAST Transporter Expression in Glial Cells

Yaneth Castro-Coronel and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 539–550, https://doi.org/10.1093/toxsci/kfr126

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REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Assessment of Fetal Brain Uptake of Paraquat In Utero Using In Vivo PET/CT Imaging

Rachel M. Bartlett and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 551–556, https://doi.org/10.1093/toxsci/kfr104

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Risk assessment

Citrinin-Generated Reactive Oxygen Species Cause Cell Cycle Arrest Leading to Apoptosis via the Intrinsic Mitochondrial Pathway in Mouse Skin

Rahul Kumar and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 557–566, https://doi.org/10.1093/toxsci/kfr143

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SAFETY EVALUATION

A Safety Evaluation of DAS181, a Sialidase Fusion Protein, in Rodents

Jeffrey L. Larson and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 567–578, https://doi.org/10.1093/toxsci/kfr109

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Hepatic Cytochrome P450s Attenuate the Cytotoxicity Induced by Leflunomide and Its Active Metabolite A77 1726 in Primary Cultured Rat Hepatocytes

Qiang Shi and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 579–586, https://doi.org/10.1093/toxsci/kfr106

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SYSTEMS TOXICOLOGY

Characterization of Organic Anion-Transporting Polypeptide (Oatp) 1a1 and 1a4 Null Mice Reveals Altered Transport Function and Urinary Metabolomic Profiles

Lei Gong and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 587–597, https://doi.org/10.1093/toxsci/kfr114

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Apoptosis-Inducing Factor Modulates Mitochondrial Oxidant Stress in Acetaminophen Hepatotoxicity

Mary Lynn Bajt and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 598–605, https://doi.org/10.1093/toxsci/kfr116

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Letters to the Editor

Reply to “Reversal and Prevention of Arsenic-Induced Human Bronchial Epithelial Cell Malignant Transformation by MicroRNA-200b”

Samuel M. Cohen

Toxicological Sciences, Volume 122, Issue 2, August 2011, Page 606, https://doi.org/10.1093/toxsci/kfr128

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Response to Concerns about Arsenic-Induced Epithelial to Mesenchymal Transition and Malignant Transformation of Human Bronchial Epithelial Cells

Chengfeng Yang

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 607–609, https://doi.org/10.1093/toxsci/kfr151

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Standing Materials

TABLE OF CONTENTS

Toxicological Sciences, Volume 122, Issue 2, August 2011, Page NP, https://doi.org/10.1093/toxsci/kfr207

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COVER

COVER

Toxicological Sciences, Volume 122, Issue 2, August 2011, Page NP, https://doi.org/10.1093/toxsci/kfr208

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Standing Materials

EDITORIAL BOARD

Toxicological Sciences, Volume 122, Issue 2, August 2011, Page NP, https://doi.org/10.1093/toxsci/kfr209

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SUBSCRIPTIONS

Toxicological Sciences, Volume 122, Issue 2, August 2011, Page NP, https://doi.org/10.1093/toxsci/kfr210

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