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Kathleen M. Sakamoto, Judith C. Gasson, Clinical applications of human granulocyte-macrophage colony-stimulating factor, The International Journal Of Cell Cloning, Volume 9, Issue 6, 1991, Pages 531–541, https://doi.org/10.1002/stem.5530090603
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Abstract
Granuloeyte-macrophage colony-stimulating factor (GM-CSF) is a hema-topoietic growth factor that stimulates myeloid cell proliferation and maturation and enhances the function of terminally differentiated effector cells. Phase I and II clinical trials have demonstrated mild to moderate toxicities at doses of less than 30 μg/kg/day. These studies suggest a potential role for this growth factor to stimulate myelopoiesis in patients with aplastic anemia, myelodysplastic syndromes, AIDS, chemotherapy-induced myelosup-pression, chronic neutropenia, and following bone marrow transplantation. The potential clinical uses of GM-CSF will depend on results of studies designed to optimize its therapeutic efficacy.