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John M. Goldman, Stephen G. O'Brien, Residual Ph-negative stem cells in chronic myeloid leukemia-sometimes or always?, Stem Cells, Volume 11, Issue S3, 1993, Pages 4–7, https://doi.org/10.1002/stem.5530110903
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Abstract
Some patients with Philadelphia (Ph) hromosome-positive chronic myeloid leukemia CML) may achieve partially or completely Ph-negtive hemopoiesis after treatment with high doses of ytotoxic drugs or interferon-α at standard dosage. This observation leads to three important questions: 1) are Ph-negative myeloid cells in such patients strictly normal? 2) can such Ph-negative ells be identified in all newly diagnosed patients or only in a minority? and 3) what is the basis for he proliferative advantage manifested by CML ells and why might it be temporarily lost as a result of treatment? The mechanisms that might prevent he proliferation of normal cells in an environment of Ph-positive cells and the relevance of these questions to the design of a strategy aimed at obtaining complete remission in the majority of patients are considered. Such a strategy might incorporate auto-grafting with Ph-negative stem cells harvested during the recovery phase of high dose chemotherapy.
