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Gino Doria, Giorgio Leter, Camillo Mancini, Daniela Frasca, Effect of recombinant il-3 on lymphocyte populations in irradiated mice, Stem Cells, Volume 11, Issue S2, 1993, Pages 93–97, https://doi.org/10.1002/stem.5530110816
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Abstract
Administration of murine recombinant interleukin 3 (IL-3) to sublethally irradiated mice induced in the thymus recovery of the cell count and mitotic responsiveness to Con A, as well as a decrease in CD4−CD8− cells concomitant with an increase in single positive cells. Also in the spleen, the cell count and mitotic responsiveness to Con A and lipopolysaccharide (LPS) were recovered by IL-3 treatment. These findings show that IL-3 induces differentiation and growth of thymocytes and recovery of T and B cell functions in sublethally irradiated mice.