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Kenneth Dorshkind, Kenneth S. Landreth, Regulation of B cell differentiation by bone marrow stromal cells, The International Journal Of Cell Cloning, Volume 10, Issue 1, 1992, Pages 12–17, https://doi.org/10.1002/stem.5530100104
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Abstract
B lymphocyte development occurs in the intersinusoidal spaces of bone marrow in association with a sessile population of stromal cells. Development of long-term bone marrow culture systems that support B lymphopoiesis has allowed the isolation of stromal cells that support that process and permitted analysis of their role in controlling the growth and differentiation of B lineage cells in culture. In addition to direct interactions with developing lymphocytes, stromal cells secrete a variety of cytokines that affect lymphocyte growth and differentiation, and many of these molecules have been expressed in recombinant form. These relatively recent advances have made it possible to formulate a working model of the cells and molecules involved in regulating primary B cell production.