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Takayuki Hosoi, Keiya Ozawa, Akio Urabe, Fumimaro Takaku, Effects of recombinant interferons on the clonogenic growth of leukemic cells and normal hemopoietic progenitors, The International Journal Of Cell Cloning, Volume 3, Issue 5, 1985, Pages 304–312, https://doi.org/10.1002/stem.5530030503
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Abstract
We have examined the effects of recombinant immune and leukocyte interferons (rIFN-γ and rIFN-a) on the clonogenic growth of leukemic cells and normal hemopoietic progenitors using in vitro colony assays. Both interferons suppressed the colony formation by granulocyte-macrophage progenitors (CFU-gm) and erythroid progenitors (CFU-e and BFU-e) in a dose-dependent manner. Six myeloid leukemic cell lines were less sensitive to rIFN-γ than CFU-gm. The colony formation of some myeloid leukemic cell lines was suppressed more potently by rIFN-α than by CFU-gm. Four lymphoid leukemic cell lines of the T-cell type were very resistant to both recombinant interferons. Reduced sensitivity of leukemic cells to rIFN-γ, a possible hemopoietic regulator, may explain partially the unregulated proliferation of leukemic cells in vivo.