... antidepressant known for its rapid and long-lasting effects. Recent studies have explored its impact on memory, yet its influence on fear memory extinction remains uncharted. Objective We investigated (2R,6R)-HNK's effects on synaptic transmission and plasticity in the basolateral amygdala (BLA) and its role...

... during RBC’s excitation. Additionally, IK mediates late repolarization and suppresses excessive oscillation of the membrane potential in the RBCs, enabling fast and transient synaptic transmission to AII amacrine cells. Our findings highlight the unique role of the IK channel in RBCs, suggesting...

... Publication Model ( https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Mitochondrial and synaptic dysfunction are pathological features of brain ageing and cognitive decline. Synaptic mitochondria are vital for meeting the high energy demands of synaptic transmission. However, little...

... in mice by increasing synapse numbers and improving synaptic transmission in hippocampal dentate gyrus and CA3 regions, but not in CA1 region. This study sheds light on the neural mechanisms underlying how early-life exercise improves cognitive function. voluntary wheel running exercise development...

...-aspartate receptor (NMDAR)- and AMPAR-mediated excitatory synaptic transmission. Our results indicate that IGF-1 microinjection in the dmPFC could attenuate fentanyl seeking and restore fentanyl-induced inhibition of excitatory synaptic transmission in the dmPFC. Insulin-like growth factor-1 (IGF-1...

... and/or γ-synuclein in the long-term regulation of dopamine reuptake. computational neuroscience dopamine fast-scan cyclic voltammetry synaptic transmission European Research Council Synergy 10.13039/501100000781 NIH 10.13039/100000002 R01DA007418 R01MH108186 Significance Statement...

... associated with frontotemporal lobar degeneration. Wang et al. report that FUS regulates synaptic transmission and neuronal-firing properties in a brain region-specific manner, and provide evidence that the synaptic dysfunction of the vHPC–mPFC circuit caused by loss of FUS underlies FTLD-linked...

... amplitudes and shorter half-widths associated with SGCE mutations. Bulk RNA sequencing analysis identified gene ontological enrichment for ‘neuron projection development’, ‘synaptic signalling’ and ‘synaptic transmission’. Examination of dendritic morphology found SGCE mutations...

... astrocyte activation by neuron-released endocannabinoids elevate astrocyte Ca²⁺ levels, stimulate ATP/adenosine release as gliotransmitters, and transiently depress synaptic transmission in layer 5 pyramidal neurons at relatively distant synapses (˃20 μm) from the stimulated neuron...

...-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected] Abstract Synaptic transmission constitutes the primary mode of communication between neurons. It is extensively studied in rodent...

... receptor cholesterol microdomain postsynaptic membrane synaptic transmission cryo-EM UK Medical Research Council 10.13039/501100000265 MC_U105184294 The 1972 ‘fluid mosaic model’ of membrane structure [ 1 ] envisioned membrane proteins as single molecules or complexes that were embedded within...

...Ana Belén Sanz-Martos; Jesús Fernández-Felipe; Beatriz Merino; Victoria Cano; Mariano Ruiz-Gayo; Nuria Del Olmo Tributyrin spatial memory LTP hippocampus synaptic transmission Significance Statement The current study investigated the effect of tributyrin, a prodrug of butyric acid, on memory...

... in trained animals. Silencing of synaptic transmission of CL neurons by the vINSIST method delayed the acquisition of CRs but did not affect their presentation rate. The CL plays an important role in the acquisition of associative learning, mostly in relation to the novelty of CS/US association...

... and frontal cortical neurons. They also demonstrate a genetic relationship between dystonia and psychiatric disorders including depression, OCD and schizophrenia. dystonia network analysis medium-spiny neurons transcriptomic analysis synaptic transmission Parkinson’s Spanish grant ‘Ayudas a los...

... of cell proliferation GO:0042127 Glutamate receptor signaling pathway GO:0007215 Release of sequestered calcium ion into cytosol GO:0051209 Negative regulation of catalytic activity GO:0043086 Synaptic transmission, glutamatergic GO:0035249 Negative regulation of intracellular...

... release on synaptic transmission and spike output in mouse hippocampal CA1 pyramidal neurons. We show that endogenous noradrenaline release enhances the probability of CA1 pyramidal neuron spiking without altering feedforward excitatory or inhibitory synaptic inputs in the Schaffer collateral pathway. β...

... and epileptic encephalopathy and describe its impact on neuroexcitability in vitro and in a novel mouse model. Receptor antagonists partially mitigate seizures in both model and patient. Abstract NMDA receptors play crucial roles in excitatory synaptic transmission. Rare variants in GRIN2A...

... lateral sclerosis parvalbumin primary motor cortex inhibitory synaptic transmission chemogenetics Mice were transcardially perfused with ice-cold phosphate-buffered saline (PBS), followed by 4% paraformaldehyde (PFA). Brains were extracted and post-fixed in 4% PFA for 16 h at 4°C and cryoprotected...

... mutations in the STXBP1 gene encoding the presynaptic protein MUNC18-1 cause STXBP1 encephalopathy, characterized by developmental delay, intellectual disability and epilepsy. Impaired mutant protein stability leading to reduced synaptic transmission is considered the main underlying...

... strategies in Huntington’s disease. cholesterol neuroprotection transcriptome synaptic transmission autophagy Mice were perfused with ice cold PBS, striata were frozen in liquid nitrogen and stored at −80°C until RNA isolation followed by reverse transcription and quantitative PCR reactions...