..., and reproduction in any medium, provided the original work is properly cited. Abstract Background Resistance to endocrine therapy in estrogen receptor–positive (ER+) breast cancer remains a significant clinical problem. Riluzole is FDA-approved for the treatment of amyotrophic lateral sclerosis. A benzothiazole...

... deficits in the hippocampus, it has the opposite effect on the amygdala. Riluzole, an FDA-approved drug known to modulate glutamate release and facilitate glutamate clearance, prevents stress-induced deficits in the hippocampus. But whether the same drug is also effective in countering the opposite effects...

.../min; µPBR: VG = 60 sccm; VL = 1.0 mL/min. In this study, a micropacked-bed reactor (µPBR) filled with Pt/BAC catalyst was successfully applied for an efficient approach of continuous flow hydrogenation of 4-TFMNB for the preparation of the key intermediate 4-TFMA of riluzole. Under the optimized...

... et al. report that riluzole slows decline of FDG PET measures of cerebral glucose metabolism—a well-established Alzheimer's disease biomarker—in several of regions of interest, with the most robust effect in posterior cingulate cortex. 31 12 2020 07 04 2021...

... domain in the US. 2014 alcohol use disorder family history ketamine major depressive disorder riluzole Major depressive disorder (MDD) has one of the highest morbidities worldwide ( Kessler et al., 2003 ; Ustun et al., 2004 ; Ormel et al., 2008 ), and, as demonstrated in large real-world...

.../standard_publication_model) Abstract Objectives The objective of this study was to explore potential drug–drug/food interactions of ciprofloxacin and grapefruit juice, known hepatic cytochrome P450 (CYP) 1A2 inhibitors, on single-dose oral pharmacokinetics of riluzole, a substrate of CYP 1A2 enzymes. Methods...

... were assessed by analysis of covariance (ANCOVA), with baseline score as a covariate, and pretreatment group (lamotrigine, placebo) as the independent variable. Time-to-relapse in phase 2 was compared across the riluzole and placebo groups with the Kaplan–Meier method and log-rank test. Safety analyses...

... and neuropathology, will be presented separately. NNIPPS was designed as a double-blind placebo-controlled, stratified (by diagnosis of MSA or PSP, and by centre), parallel group, European (France, Germany, United Kingdom) trial assessing the efficacy and safety of riluzole at flexible dose (50–200 mg/day) ( Fig. 1...

... considerable laboratory based research. The diagnosis must be given with care and consideration and close follow up is essential. Management involves a multidisciplinary team based in the hospital and the community. Riluzole is the only drug shown to have a disease modifying effect and has been approved...

... 2 weeks later, no more than 24 hours before they were killed. 27 12 2001 13 03 2002 Abstract OBJECTIVE Hydrocephalus causes damage to periventricular white matter at least in part through chronic ischemia. The sodium channel-blocking agents mexiletine and riluzole have been shown...

... : Recent studies confirmed the deleterious role of glutamate in the pathophysiology of spinal cord ischemia induced by aortic cross-clamping. We investigated the effect of riluzole, an anti-glutamate drug, in a rat model of spinal cord ischemia. Materials and methods : Spinal cord ischemia was induced...

...Oxford University Press This chapter provides a summary of a landmark study in neuromuscular disease. Is there a benefit in terms of survival and functional status to treating patients with amyotrophic lateral sclerosis with riluzole? Starting with that question, it describes the basics...

... spongiform encephalopathies; use of Riluzole as the approved therapy for ALS; the major inflammatory component of ALS; a Guamanian disorder that is biochemically and ultrastructurally similar to that of Alzheimer’s disease; and awareness that the true onset of ALS is unknown but certainly precedes clinical...

... polygenetic profile fasciculation bulbar onset dysarthria preceding dysphagia milder cognitive deficit limb weakness respiratory failure sudden death progressive muscle weakness EMG riluzole non-invasive ventilation amyotrophic lateral sclerosis ALS frontotemporal dementia FTD motor neuron...

...Oxford University Press This chapter on motor neuron disease (MND) discusses the classification, clinical presentations, and treatments available for the major MND subtype amyotrophic lateral sclerosis (ALS). motor neuron disease MND amyotrophic lateral sclerosis ALS edaravone riluzole sodium...

..., including therapeutic hypothermia, sodium channel blockade using riluzole, and the anti-inflammatory actions of minocycline. The chapter concludes by summarizing the current guidelines that all practitioners should be well-versed in prior to providing care for patients with SCI. spinal cord injury riluzole...

..., C9orf72, SQSTM1, VCP, UBQLN2 and others—a unifying pathological feature (TDP-43 accumulation) has been found, and a modestly effective treatment (riluzole) has become available. Charcot J M lower motor neurons sequestrome Babinski’s sign...

...Oxford University Press Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with limited treatment options and a median survival of 24–48 months. This study calculated the incidence and prevalence of ALS and explored the effect of riluzole exposure on survival. Results...

... it is today. With the discovery of the SOD1 gene mutation in the early 1990s, a new era of excitement and innovation for ALS research began. Since then, the number of ALS trials has steadily increased and trial design and methodology has become increasingly sophisticated. clinical trials ALS SOD riluzole...

... galactorrhea methylphenidate nonstimulants pediatrician riluzole seizure disorders tardive dyskinesia There are numerous ways that a child might first present to a child psychiatrist. Most patients who present to my office are referred by pediatricians or therapists because the parent or the professional...