...) neurodegeneration neuroprotection sex differences tRNA mutations ACCEPTED MANUSCRIPT 1 REVIEW ARTICLE 2 Emerging roles of transfer RNA fragments in the CNS 3 Katarzyna Winek1 and Hermona Soreq2,3 4 Abstract 5 tRNA-derived small RNAs (tsRNAs), previously considered inactive tRNA degradation products, 6 have now...

..., such as multiple sclerosis. Abdelhak et al. show that blood levels of neurofilament light chain reflect potentially reversible demyelination-induced nerve fibre injury in animal models of multiple sclerosis as well as in patients. neurofilament light chain multiple sclerosis neuroprotection...

... neuroprotection stroke ACCEPTED MANUSCRIPT 1 CXCR3-mediated natural killer cell infiltration exacerbates 2 white matter injury after intracerebral haemorrhage 3 Anson C. K. Ng,1 Cuiting Zhang,1 Tsz Lung Lam,1 Karrie M. Kiang,1 Vaness N. C. Ng,2 Zhiyuan 4 Zhu,1,3 Jiaxin Liu,1 Wenwei Tu,4 Wanjun Tang,1 Katrina C...

... levels reflect oxidative damage to cellular membranes and are implicated in the pathogenesis of NDs. Assessing LDH release alongside MDA levels provides a robust framework for evaluating the efficacy of potential neuroprotective agents in countering redox and apoptotic damage. ¹²...

..., specifically tailored to target NMDARs within distinct cellular populations in the brain. NMDA receptors conantokin toxins gene delivery pharmacogenetic tools neuroprotection Israel Science Foundation 10.13039/501100003977 Significance Statement NMDA receptors (NMDARs) are crucial glutamate receptors...

... of accounting for functional and structural heterogeneity in receptor–ligand interactions, illustrates chemical biology strategies to develop isoform-selective agents, validates TrkC.T1 as a druggable target, and expands the therapeutic concept of reducing neurotoxicity as a strategy to achieve neuroprotection...

... this vulnerable population. Future CHR research might use similar models to develop a “protective index” to predict resilient outcomes. prodrome schizophrenia neuroprotection National Institute of Mental Health 10.13039/100000025 U01MH081984 U01MH081928 U01MH081944 U01MH081902 U01MH082004 U01MH081988...

.... ⁴ To improve outcome after cardiac arrest, there is a pressing need for effective treatments to prevent secondary injury and promote brain recovery after a hypoxic insult. More than 20 potential neuroprotective treatments have been tested in clinical trials, but none showed unequivocal...

... for cognitive activity, but also capturing excess (toxic) Zn²⁺ involved in cognitive decline and neurodegeneration. Therefore, it is estimated that regulation of MT synthesis is involved in both neuronal activity and neuroprotection. The present report provides recent knowledge regarding...

..., are reported to be resistant to available treatments. We assessed the therapeutic potential of Garcinia kola, a medicinal plant reported to have antiplasmodial and neuroprotective properties, against experimental toxoplasmosis in rats. Severe toxoplasmosis was induced in male Wistar rats (156.7 ± 4.1...

...Viswanthram Palanivel; Vivek Gupta; Nitin Chitranshi; Ole Tietz; Roshana Vander Wall; Reuben Blades; Kanishka Pushpitha Maha Thananthirige; Akanksha Salkar; Chao Shen; Mehdi Mirzaei; Veer Gupta; Stuart L Graham; Devaraj Basavarajappa; Andrey Abramov The neuroprotective capabilities of NPY against...

... (ACh) levels (12%), and decreased acetylcholine esterase (AChE) activity (~50%). Since it has been known for centuries that WO does show any adverse effects on human health and has neuroprotective properties, it may be used in the treatment of AD as an additional nutraceutical to drug treatments...

...-Tau phosphorylation; these effects were reversed by the SIRT1 inhibitor EX527. SYR exerts neuroprotective effects on sevoflurane-induced cognitive dysfunction by modulating glial activity, apoptotic signaling, and Tau phosphorylation through the SIRT1 pathway. These findings could inform clinical...

... and counteracting neuronal death in the aluminum chloride mice model, suggesting its increased bioavailability at the brain level. Conclusions The glycosylation of CHR with β-d-glucose tetraacetate amplifies its neuroprotective effects, positioning LQFM280 as a promising lead compound for safeguarding...

... myelin imaging neuroprotection neurodegeneration Overall, 180 patients who met the 2010 diagnostic criteria of MS ¹⁹ were followed up at four European centres of the MAGNIMS consortium (Graz, Milan, Paris, Siena) and enrolled in this retrospective longitudinal clinico-radiological...

...Matteo Haupt; Stefan T Gerner; Hagen B Huttner; Thorsten R Doeppner Significance Statement The role of extracellular vesicles (EVs) derived from various cell types has emerged as neuroprotectants in preclinical stroke models. Interestingly, the efficacy of these EVs appears to be enhanced when...

... in the mediation of cerebral injury and in the behavioral outcome of ischemic brain injuries, which points to treatment with G1 as a potential pharmacological strategy for the therapy of stroke. Cerebral infarct Estrogen GPER1 MCAO Neuropharmacology Neuroprotection Stroke PROPESP-UFPA Stroke is an acute...

... resulting from the loss of neuronal cells in the brain and spinal cord. In this experiment, we investigated the neuroprotective and antioxidant effects of farrerol on glutamate-induced HT22 cells. Our results showed that farrerol inhibited reactive oxygen species expression, apoptosis, mitochondrial damage...

... described the neuroprotective effects of acidosis or hypoxia post-conditioning that prevent ΔΨm loss in ischemic neurons but reinforce Parkin-mediated mitophagy [ 14 , 23 , 61 ]. These observations suggest the involvement of other factors besides ΔΨm loss in provoking PINK1–Parkin signaling. As discussed...

...Mahla Daliri; Thomas P Johnston; Amirhossein Sahebkar statin peripheral neuropathy neuroprotection HMG-CoA reductase inhibitors atorvastatin rosuvastatin simvastatin lipid Several groups have investigated the capacity of atorvastatin to ameliorate diabetic neuropathy. A study conducted...